Transcription factor AP-4 (Q21133097)

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mammalian protein found in Homo sapiens

class C basic helix-loop-helix protein 41
transcription factor AP-4 (activating enhancer binding protein 4)
bHLHc41
TFAP4
transcription factor AP-4
activating enhancer-binding protein 4

Language	Label	Description	Also known as
English	Transcription factor AP-4	mammalian protein found in Homo sapiens	class C basic helix-loop-helix protein 41 transcription factor AP-4 (activating enhancer binding protein 4) bHLHc41 TFAP4 transcription factor AP-4 activating enhancer-binding protein 4

Statements

1 reference

13 November 2019

UniProt protein ID

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01664

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

sequence-specific DNA binding

determination method

1 reference

8 April 2019

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

protein dimerization activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

histone deacetylase binding

determination method

3 references

8 April 2019

Transcriptional repression of human immunodeficiency virus type 1 by AP-4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

10 September 2018

Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

protein binding

determination method

3 references

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

determination method

6 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

AP4 encodes a c-MYC-inducible repressor of p21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

determination method

8 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

27 March 2018

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

27 March 2018

Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

27 March 2018

Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

27 March 2018

Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

27 March 2018

Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

27 March 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

determination method

9 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

biological process

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

AP4 encodes a c-MYC-inducible repressor of p21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

negative regulation of cyclin-dependent protein serine/threonine kinase activity

determination method

1 reference

8 April 2019

AP4 encodes a c-MYC-inducible repressor of p21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

determination method

1 reference

8 April 2019

AP4 encodes a c-MYC-inducible repressor of p21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

cellular response to dexamethasone stimulus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

AP4 encodes a c-MYC-inducible repressor of p21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

regulation of transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01664&geneProductId=UniProtKB:Q01664

determination method

negative regulation of transcription, DNA-templated

determination method

5 references

8 April 2019

AP4 encodes a c-MYC-inducible repressor of p21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

8 April 2019

A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

regulation of mitotic cell cycle phase transition

determination method

1 reference

8 April 2019

AP4 encodes a c-MYC-inducible repressor of p21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01664

determination method

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01664

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000204517

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000204517

ENSP00000459390

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000459390

ENSP00000460067

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460067

ENSP00000461352

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000461352

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