Protein arginine methyltransferase 2 (Q21131670)

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mammalian protein found in Homo sapiens

histone-arginine N-methyltransferase PRMT2
PRMT2 beta
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1
HMT1 hnRNP methyltransferase-like 1
PRMT2
PRMT2 gamma
protein arginine N-methyltransferase 2
PRMT2 alpha

Language	Label	Description	Also known as
English	Protein arginine methyltransferase 2	mammalian protein found in Homo sapiens	histone-arginine N-methyltransferase PRMT2 PRMT2 beta HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1 HMT1 hnRNP methyltransferase-like 1 PRMT2 PRMT2 gamma protein arginine N-methyltransferase 2 PRMT2 alpha

Statements

1 reference

13 November 2019

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55345

S-adenosyl-L-methionine-dependent methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55345

Protein arginine N-methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55345

Methyltransferase small domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

histone methyltransferase activity

determination method

1 reference

8 April 2019

Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

progesterone receptor binding

determination method

1 reference

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

signal transducer activity

determination method

1 reference

1 January 2018

Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55345&geneProductId=UniProtKB:P55345

determination method

thyroid hormone receptor binding

determination method

1 reference

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

protein binding

determination method

9 references

8 April 2019

Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

The arginine methyltransferase PRMT2 binds RB and regulates E2F function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

androgen receptor binding

determination method

1 reference

8 April 2019

PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

peroxisome proliferator activated receptor binding

determination method

1 reference

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

retinoic acid receptor binding

determination method

1 reference

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

estrogen receptor binding

determination method

protein-arginine N-methyltransferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

protein-arginine omega-N asymmetric methyltransferase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

protein-containing complex binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55345&geneProductId=UniProtKB:P55345

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

determination method

4 references

8 April 2019

Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

determination method

3 references

8 April 2019

PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

biological process

developmental cell growth

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

negative regulation of G1/S transition of mitotic cell cycle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

regulation of androgen receptor signaling pathway

determination method

1 reference

8 April 2019

PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

signal transduction

determination method

1 reference

8 April 2019

Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

histone arginine methylation

determination method

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55345&geneProductId=UniProtKB:P55345

determination method

peptidyl-arginine N-methylation

determination method

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55345&geneProductId=UniProtKB:P55345

determination method

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

determination method

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55345&geneProductId=UniProtKB:P55345

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

histone arginine methylation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55345

determination method

EC enzyme number

2.1.1.125

reason for deprecated rank

deprecated identifier value

1 reference

22 April 2020

2.1.1.321

1 reference

22 April 2020

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55345

Methyltransferase small domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55345

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000291705

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000291705

ENSP00000335490

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000335490

ENSP00000347906

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000347906

ENSP00000380759

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380759

ENSP00000380760

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380760

ENSP00000397266

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397266

ENSP00000407463

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407463

ENSP00000411984

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411984

ENSP00000380752

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380752

ENSP00000406127

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000406127

ENSP00000482158

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000482158

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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