Heat shock protein 90 beta family member 1 (Q21131370)

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mammalian protein found in Homo sapiens

stress-inducible tumor rejection antigen gp96
tumor rejection antigen (gp96) 1
epididymis luminal protein 35
94 kDa glucose-regulated protein
heat shock protein 90 kDa beta member 1
HSP90B1
heat shock protein 90kDa beta family member 1
endoplasmin
endothelial cell (HBMEC) glycoprotein
epididymis secretory sperm binding protein Li 125m
heat shock protein 90kDa beta (Grp94), member 1
tumor rejection antigen 1
gp96 homolog
GRP-94

Language	Label	Description	Also known as
English	Heat shock protein 90 beta family member 1	mammalian protein found in Homo sapiens	stress-inducible tumor rejection antigen gp96 tumor rejection antigen (gp96) 1 epididymis luminal protein 35 94 kDa glucose-regulated protein heat shock protein 90 kDa beta member 1 HSP90B1 heat shock protein 90kDa beta family member 1 endoplasmin endothelial cell (HBMEC) glycoprotein epididymis secretory sperm binding protein Li 125m heat shock protein 90kDa beta (Grp94), member 1 tumor rejection antigen 1 gp96 homolog GRP-94

Statements

1 reference

13 November 2019

UniProt protein ID

HSP90, C-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14625

Ribosomal protein S5 domain 2-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14625

heat shock protein Hsp90 family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14625

Histidine kinase/HSP90-like ATPase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14625

Histidine kinase/HSP90-like ATPase family

1 reference

based on heuristic

inferred from protein domain or family

Heat shock protein Hsp90, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Heat shock protein Hsp90, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

calcium ion binding

determination method

1 reference

8 April 2019

The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

unfolded protein binding

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

low-density lipoprotein particle receptor binding

determination method

1 reference

8 April 2019

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

protein binding

determination method

10 references

8 April 2019

Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

determination method

1 reference

8 April 2019

Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

protein phosphatase binding

determination method

1 reference

8 April 2019

Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

determination method

2 references

protein binding

determination method

11 references

1 January 2018

Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

determination method

1 reference

8 April 2019

Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

endocytic vesicle lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

endoplasmic reticulum lumen

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

extracellular matrix

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

plasma membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

endoplasmic reticulum chaperone complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

extracellular region

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

determination method

1 reference

8 April 2019

Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

endoplasmic reticulum

determination method

5 references

17 October 2017

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

17 October 2017

Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

17 October 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

perinuclear region of cytoplasm

determination method

1 reference

17 October 2017

The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

extracellular exosome

determination method

determination method

1 reference

17 October 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

determination method

1 reference

8 April 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

endoplasmic reticulum

determination method

6 references

8 April 2019

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

protein-containing complex

determination method

1 reference

8 April 2019

A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

perinuclear region of cytoplasm

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

extracellular exosome

determination method

biological process

response to hypoxia

determination method

1 reference

8 April 2019

Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

response to stress

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14625&geneProductId=UniProtKB:P14625

determination method

protein folding in endoplasmic reticulum

determination method

1 reference

8 April 2019

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

negative regulation of apoptotic process

determination method

3 references

8 April 2019

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

8 April 2019

The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

receptor-mediated endocytosis

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

response to endoplasmic reticulum stress

determination method

1 reference

8 April 2019

The endoplasmic reticulum stress response in aging and age-related diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

regulation of phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

ATF6-mediated unfolded protein response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

actin rod assembly

determination method

1 reference

8 April 2019

Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

retrograde protein transport, ER to cytosol

determination method

1 reference

8 April 2019

Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

sequestering of calcium ion

determination method

1 reference

8 April 2019

GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

protein folding

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

ubiquitin-dependent ERAD pathway

determination method

1 reference

1 January 2018

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

protein transport

determination method

1 reference

8 April 2019

Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

cellular response to ATP

determination method

1 reference

8 April 2019

Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

post-translational protein modification

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14625

determination method

Heat shock protein Hsp90, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14625

Histidine kinase/HSP90-like ATPase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14625

Heat shock protein Hsp90, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14625

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000299767

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000299767

ENSP00000446266

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446266

ENSP00000446748

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446748

ENSP00000450215

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450215

ENSP00000477660

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477660

ENSP00000492386

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492386

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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