KN motif and ankyrin repeat domains 1 (Q21131022)

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mammalian protein found in Homo sapiens

KN motif and ankyrin repeat domain-containing protein 1
ankyrin repeat domain-containing protein 15
KANK1
kidney ankyrin repeat-containing protein

Language	Label	Description	Also known as
English	KN motif and ankyrin repeat domains 1	mammalian protein found in Homo sapiens	KN motif and ankyrin repeat domain-containing protein 1 ankyrin repeat domain-containing protein 15 KANK1 kidney ankyrin repeat-containing protein

Statements

1 reference

13 November 2019

UniProt protein ID

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14678

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Kank N-terminal motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

beta-catenin binding

determination method

1 reference

8 April 2019

Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

protein binding

determination method

6 references

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

A major mutation of KIF21A associated with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) enhances translocation of Kank1 to the membrane

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

biological process

negative regulation of neuron projection development

determination method

1 reference

8 April 2019

Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

regulation of transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14678&geneProductId=UniProtKB:Q14678

determination method

negative regulation of actin filament polymerization

determination method

negative regulation of ruffle assembly

determination method

1 reference

8 April 2019

Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

negative regulation of Rho protein signal transduction

determination method

1 reference

8 April 2019

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

positive regulation of wound healing

determination method

1 reference

8 April 2019

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14678&geneProductId=UniProtKB:Q14678

determination method

positive regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

negative regulation of insulin receptor signaling pathway

determination method

1 reference

8 April 2019

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

negative regulation of cell migration

determination method

1 reference

8 April 2019

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

negative regulation of lamellipodium morphogenesis

determination method

1 reference

8 April 2019

Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

negative regulation of substrate adhesion-dependent cell spreading

determination method

1 reference

8 April 2019

Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

regulation of establishment of cell polarity

determination method

1 reference

8 April 2019

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

positive regulation of canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

negative regulation of actin filament polymerization

determination method

3 references

8 April 2019

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

Kank proteins: a new family of ankyrin-repeat domain-containing proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

regulation of Rho protein signal transduction

determination method

1 reference

8 April 2019

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

glomerular visceral epithelial cell migration

determination method

1 reference

8 April 2019

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

cell population proliferation

determination method

1 reference

8 April 2019

A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

actin cytoskeleton organization

determination method

1 reference

8 April 2019

A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14678

determination method

ankyrin repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14678

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14678

Kank N-terminal motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14678

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000371730

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000371730

ENSP00000371734

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000371734

ENSP00000371740

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000371740

ENSP00000477725

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477725

ENSP00000371723

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000371723

ENSP00000371726

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000371726

ENSP00000501167

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000501167

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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