Farnesyltransferase, CAAX box, beta (Q21130772)

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mammalian protein found in Homo sapiens
  • CAAX farnesyltransferase subunit beta
  • epididymis secretory sperm binding protein
  • FTase-beta
  • FNTB
  • CHURC1-FNTB
  • protein farnesyltransferase subunit beta
  • ras proteins prenyltransferase subunit beta
  • CHURC1-FNTB protein
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Language Label Description Also known as
English
Farnesyltransferase, CAAX box, beta
mammalian protein found in Homo sapiens
  • CAAX farnesyltransferase subunit beta
  • epididymis secretory sperm binding protein
  • FTase-beta
  • FNTB
  • CHURC1-FNTB
  • protein farnesyltransferase subunit beta
  • ras proteins prenyltransferase subunit beta
  • CHURC1-FNTB protein

Statements

molecular function
protein binding
determination method
IPI
6 references
retrieved
8 April 2019
stated in
Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356
determination method
IPI
retrieved
8 April 2019
stated in
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356
determination method
IPI
retrieved
8 April 2019
stated in
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356
determination method
IPI
retrieved
8 April 2019
stated in
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356
determination method
IPI
retrieved
8 April 2019
stated in
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49356
determination method
IPI
cell component
biological process

Identifiers

PDB structure ID
 
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