Phospholipase C epsilon 1 (Q21125899)

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mammalian protein found in Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
PLCE1
phosphoinositide-specific phospholipase C epsilon-1
Phospholipase C-epsilon-1
phosphoinositide phospholipase C-epsilon-1
PLC-epsilon-1
pancreas-enriched phospholipase C
phosphoinositide phospholipase C

Language	Label	Description	Also known as
English	Phospholipase C epsilon 1	mammalian protein found in Homo sapiens	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 PLCE1 phosphoinositide-specific phospholipase C epsilon-1 Phospholipase C-epsilon-1 phosphoinositide phospholipase C-epsilon-1 PLC-epsilon-1 pancreas-enriched phospholipase C phosphoinositide phospholipase C

Statements

1 reference

13 November 2019

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

Ras guanine nucleotide exchange factor domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

Ras-associating (RA) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ras guanine-nucleotide exchange factors catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol-specific phospholipase C, X domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phospholipase C, phosphatidylinositol-specific, Y domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphoinositide-specific phospholipase C, EF-hand-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

guanyl-nucleotide exchange factor activity

determination method

3 references

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

signal transducer activity

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

protein binding

determination method

1 reference

24 April 2018

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

phosphoric diester hydrolase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

determination method

1 reference

8 April 2019

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

phospholipase C activity

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

phosphatidylinositol phospholipase C activity

determination method

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

24 April 2018

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

24 April 2018

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

phosphatidylinositol phospholipase C activity

determination method

6 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

7 November 2018

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

7 November 2018

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

phosphatidylinositol phospholipase C activity

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

plasma membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

8 April 2019

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

biological process

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

epidermal growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

regulation of G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

regulation of smooth muscle contraction

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

small GTPase mediated signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

regulation of Ras protein signal transduction

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

glomerulus development

determination method

1 reference

8 April 2019

Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

inositol phosphate metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

diacylglycerol biosynthetic process

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

lipid catabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

phospholipase C-activating G protein-coupled receptor signaling pathway

determination method

heart development

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

cytoskeleton organization

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

regulation of cell growth

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

regulation of protein kinase activity

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

inositol phosphate-mediated signaling

determination method

1 reference

8 April 2019

A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

calcium-mediated signaling

determination method

Ras protein signal transduction

determination method

1 reference

24 April 2018

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9P212&geneProductId=UniProtKB:Q9P212

determination method

inositol trisphosphate biosynthetic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

phosphatidylinositol-mediated signaling

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

release of sequestered calcium ion into cytosol

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9P212

determination method

Phosphoinositide-specific phospholipase C, EF-hand-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

Phosphatidylinositol-specific phospholipase C, X domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

Phospholipase C, phosphatidylinositol-specific, Y domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

Ras-associating (RA) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

Ras guanine-nucleotide exchange factors catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9P212

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000360426

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360426

ENSP00000360431

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360431

ENSP00000360438

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360438

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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