Notch receptor 2 (Q21124891)

Notch-like domain superfamily

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Ankyrin repeat-containing domain superfamily

1 reference

Notch, NODP domain, protein family

1 reference

Notch proteins

1 reference

Notch, NOD domain, protein family

1 reference

Domain of unknown function DUF3454, notch, protein family

1 reference

Ankyrin repeat-containing domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

Ankyrin repeat, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

1 reference

16 January 2019

1 reference

16 January 2019

1 reference

9 May 2019

8 references

9 May 2019

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

Human ligands of the Notch receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

endoplasmic reticulum membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

8 April 2019

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

integral component of plasma membrane

1 reference

9 May 2019

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

1 reference

8 April 2019

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

IBA

biological process

Notch signaling pathway

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

8 April 2019

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

8 April 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

1 reference

9 May 2019

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

pulmonary valve morphogenesis

1 reference

9 May 2019

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

regulation of transcription, DNA-templated

IMP

3 references

31 October 2017

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04721&geneProductId=UniProtKB:Q04721

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04721&geneProductId=UniProtKB:Q04721

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04721&geneProductId=UniProtKB:Q04721

positive regulation of Ras protein signal transduction

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

negative regulation of apoptotic process

1 reference

9 May 2019

Notch2 protein distribution in human teeth under normal and pathological conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

marginal zone B cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

transcription, DNA-templated

ISS

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04721&geneProductId=UniProtKB:Q04721

nervous system development

1 reference

9 May 2019

Expression of Wnt and Notch pathway genes in a pluripotent human embryonal carcinoma cell line and embryonic stem cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

stem cell population maintenance

NAS

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

multicellular organism development

NAS

atrial septum morphogenesis

3 references

1 reference

9 May 2019

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

regulation of developmental process

IMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

animal organ morphogenesis

1 reference

9 May 2019

Notch2 protein distribution in human teeth under normal and pathological conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

transcription initiation from RNA polymerase II promoter

IEP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

Notch signaling involved in heart development

1 reference

9 May 2019

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

1 reference

9 May 2019

Notch2 protein distribution in human teeth under normal and pathological conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

cell fate determination

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

intracellular receptor signaling pathway

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04721&geneProductId=UniProtKB:Q04721

negative regulation of gene expression

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

negative regulation of growth rate

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

regulation of osteoclast development

1 reference

9 May 2019

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

positive regulation of keratinocyte proliferation

IMP

1 reference

9 May 2019

Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

regulation of actin cytoskeleton reorganization

1 reference

9 May 2019

Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

Notch signaling pathway

6 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

Notch signaling induces cell cycle arrest in small cell lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04721

EGF-type aspartate/asparagine hydroxylation site

IBA

has part(s)

1 reference

Notch domain

1 reference

EGF-like calcium-binding, conserved site

1 reference

Notch, NODP domain

1 reference

ankyrin repeat-containing domain

1 reference

Notch, NOD domain

1 reference

EGF-like, conserved site

1 reference

Domain of unknown function DUF3454, notch

1 reference

ankyrin repeat

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like domain

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

D051883

subject named as

Receptor, Notch2

0 references

MeSH tree code

D12.776.543.750.725.750

0 references

0 references

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

16 January 2019

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

language of work or name

1 reference