UPF2 regulator of nonsense mediated mRNA decay (Q21124873)

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mammalian protein found in Homo sapiens
  • UPF2
  • LEMD3/UPF2 fusion
  • smg-3 homolog, nonsense mediated mRNA decay factor
  • FRS2/UPF2/LEMD3 fusion
  • up-frameshift suppressor 2 homolog
  • regulator of nonsense transcripts 2
  • yeast Upf2p homolog
  • nonsense mRNA reducing factor 2
  • UPF2 regulator of nonsense transcripts homolog
  • hUpf2
edit
Language Label Description Also known as
English
UPF2 regulator of nonsense mediated mRNA decay
mammalian protein found in Homo sapiens
  • UPF2
  • LEMD3/UPF2 fusion
  • smg-3 homolog, nonsense mediated mRNA decay factor
  • FRS2/UPF2/LEMD3 fusion
  • up-frameshift suppressor 2 homolog
  • regulator of nonsense transcripts 2
  • yeast Upf2p homolog
  • nonsense mRNA reducing factor 2
  • UPF2 regulator of nonsense transcripts homolog
  • hUpf2

Statements

molecular function
protein binding
determination method
IPI
27 references
retrieved
8 April 2019
stated in
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q9HAU5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA
GOA
curator
UniProt
UniProt protein ID
Q9HAU5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q9HAU5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Human INT6/eIF3e is required for nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q9HAU5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Results of the determination of serum markers in patients with malignant melanoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
A protein interaction framework for human mRNA degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
A UPF3-mediated regulatory switch that maintains RNA surveillance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
retrieved
8 April 2019
stated in
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IPI
cell component
biological process
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
determination method
IBA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
Human INT6/eIF3e is required for nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q9HAU5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
TAS
retrieved
8 April 2019
stated in
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
TAS
retrieved
8 April 2019
stated in
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA
GOA
curator
UniProt
UniProt protein ID
Q9HAU5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HAU5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5
determination method
IBA

Identifiers

 
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