Wnt family member 2 (Q21123963)

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mammalian protein found in Homo sapiens

epididymis secretory sperm binding protein
WNT2
Int-1-related protein
int-1-like protein 1
wingless-type MMTV integration site family member 2
IRP
protein Wnt-2
secreted growth factor

Language	Label	Description	Also known as
English	Wnt family member 2	mammalian protein found in Homo sapiens	epididymis secretory sperm binding protein WNT2 Int-1-related protein int-1-like protein 1 wingless-type MMTV integration site family member 2 IRP protein Wnt-2 secreted growth factor

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09544

Wnt protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

frizzled binding

determination method

signaling receptor binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

cytokine activity

determination method

1 reference

8 April 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

protein binding

determination method

1 reference

8 April 2019

Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

receptor ligand activity

determination method

frizzled binding

determination method

3 references

8 April 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Overexpression of Wnt-2 in colorectal cancers

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

extracellular matrix

determination method

1 reference

10 September 2018

The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

Wnt signalosome

determination method

1 reference

8 April 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

plasma membrane

determination method

1 reference

24 April 2018

Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

extracellular region

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

extracellular space

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

extrinsic component of external side of plasma membrane

determination method

1 reference

8 April 2019

Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

biological process

positive regulation of mesenchymal cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

positive regulation of cardiac muscle cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

positive regulation of endothelial cell proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

mammary gland epithelium development

determination method

1 reference

8 April 2019

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

lung development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

positive regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

determination method

1 reference

8 April 2019

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

lens development in camera-type eye

determination method

1 reference

8 April 2019

Expression patterns of Wnt genes during development of an anterior part of the chicken eye

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

cardiac epithelial to mesenchymal transition

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

cellular response to retinoic acid

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

iris morphogenesis

determination method

1 reference

8 April 2019

Expression patterns of Wnt genes during development of an anterior part of the chicken eye

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

cellular response to transforming growth factor beta stimulus

determination method

1 reference

8 April 2019

Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

positive regulation of epithelial cell proliferation involved in lung morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

cell fate commitment

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

labyrinthine layer blood vessel development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

positive regulation of fibroblast proliferation

determination method

1 reference

8 April 2019

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

atrial cardiac muscle tissue morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

positive regulation of canonical Wnt signaling pathway

determination method

1 reference

21 June 2018

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

canonical Wnt signaling pathway

determination method

4 references

21 June 2018

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

21 June 2018

Wnt2 regulates progenitor proliferation in the developing ventral midbrain

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

21 June 2018

Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

neuron differentiation

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

midbrain dopaminergic neuron differentiation

determination method

1 reference

8 April 2019

Wnt2 regulates progenitor proliferation in the developing ventral midbrain

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

determination method

1 reference

8 April 2019

Wnt2 regulates progenitor proliferation in the developing ventral midbrain

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

Wnt signaling pathway

determination method

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

21 June 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

cell proliferation in midbrain

determination method

1 reference

8 April 2019

Wnt2 regulates progenitor proliferation in the developing ventral midbrain

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

Wnt signaling pathway

determination method

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09544&geneProductId=UniProtKB:P09544

determination method

canonical Wnt signaling pathway

determination method

6 references

8 April 2019

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Wnt2 regulates progenitor proliferation in the developing ventral midbrain

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

Wnt signaling pathway

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09544

determination method

Wnt protein, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09544

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000265441

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000265441

ENSP00000389643

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389643

ENSP00000419466

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419466

ENSP00000497695

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497695

Sitelinks

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