UDP glucuronosyltransferase family 1 member A4 (Q21123552)

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mammalian protein found in Homo sapiens

UDP-glucuronosyltransferase 1A4
UDP-glucuronosyltransferase 1A1
hUG-BR2
UGT-1D
UGT1D
UDP-glucuronosyltransferase 1-1
UDP-glucuronosyltransferase 1-A
bilirubin-specific UDPGT isozyme 2
UDPGT 1-1
UGT1A4
UDP-glucuronosyltransferase 1-D
UDP glycosyltransferase 1 family, polypeptide A4
UDP glucuronosyltransferase 1 family, polypeptide A4
Bilirubin-specific UDPGT isozyme 1
UDP-glucuronosyltransferase 1 family polypeptide A4s
bilirubin UDP-glucuronosyltransferase isozyme 2
UDP-glucuronosyltransferase 1-4

Language	Label	Description	Also known as
English	UDP glucuronosyltransferase family 1 member A4	mammalian protein found in Homo sapiens	UDP-glucuronosyltransferase 1A4 UDP-glucuronosyltransferase 1A1 hUG-BR2 UGT-1D UGT1D UDP-glucuronosyltransferase 1-1 UDP-glucuronosyltransferase 1-A bilirubin-specific UDPGT isozyme 2 UDPGT 1-1 UGT1A4 UDP-glucuronosyltransferase 1-D UDP glycosyltransferase 1 family, polypeptide A4 UDP glucuronosyltransferase 1 family, polypeptide A4 Bilirubin-specific UDPGT isozyme 1 UDP-glucuronosyltransferase 1 family polypeptide A4s bilirubin UDP-glucuronosyltransferase isozyme 2 UDP-glucuronosyltransferase 1-4

Statements

1 reference

13 November 2019

UniProt protein ID

UDP-glucuronosyl/UDP-glucosyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22310

UDP-glycosyltransferase family, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

retinoic acid binding

determination method

1 reference

8 April 2019

Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

hexosyltransferase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

glycosyltransferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

protein heterodimerization activity

determination method

2 references

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

determination method

1 reference

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

glucuronosyltransferase activity

determination method

6 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

UDP-glycosyltransferase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

glucuronosyltransferase activity

determination method

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

1 January 2018

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

1 January 2018

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

glucuronosyltransferase activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

8 April 2019

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

8 April 2019

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

endoplasmic reticulum membrane

determination method

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

intracellular membrane-bounded organelle

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

endoplasmic reticulum

determination method

3 references

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

biological process

negative regulation of cellular glucuronidation

determination method

1 reference

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

heme catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

cellular glucuronidation

determination method

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

27 February 2018

Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

xenobiotic glucuronidation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

negative regulation of glucuronosyltransferase activity

determination method

1 reference

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

negative regulation of fatty acid metabolic process

determination method

1 reference

27 February 2018

Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22310&geneProductId=UniProtKB:P22310

determination method

bilirubin conjugation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

flavonoid glucuronidation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22310

determination method

UDP-glycosyltransferase family, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22310

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000362508

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362508

ENSP00000408608

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408608

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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