Ubiquitin specific peptidase 13 (Q21123531)

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mammalian protein found in Homo sapiens

ubiquitin carboxyl-terminal hydrolase 13
deubiquitinating enzyme 13
ISOT-3
ubiquitin thioesterase 13
ubiquitin-specific-processing protease 13
USP13
ubiquitin thiolesterase 13
ubiquitin specific protease 13 (isopeptidase T-3)
ubiquitin specific peptidase 13 (isopeptidase T-3)
Isopeptidase T-3

Language	Label	Description	Also known as
English	Ubiquitin specific peptidase 13	mammalian protein found in Homo sapiens	ubiquitin carboxyl-terminal hydrolase 13 deubiquitinating enzyme 13 ISOT-3 ubiquitin thioesterase 13 ubiquitin-specific-processing protease 13 USP13 ubiquitin thiolesterase 13 ubiquitin specific protease 13 (isopeptidase T-3) ubiquitin specific peptidase 13 (isopeptidase T-3) Isopeptidase T-3

Statements

1 reference

13 November 2019

UniProt protein ID

UBA-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Ubiquitinyl hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Peptidase C19, ubiquitin carboxyl-terminal hydrolase family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, UBP-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin specific protease domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin specific protease, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cysteine-type peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

chaperone binding

determination method

1 reference

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

BAT3 complex binding

determination method

1 reference

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

ubiquitin-like protein-specific protease activity

determination method

1 reference

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

proteasome binding

determination method

1 reference

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

ubiquitin binding

determination method

3 references

8 April 2019

USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Regulation of MITF stability by the USP13 deubiquitinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

ubiquitin-like protein ligase binding

determination method

1 reference

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

thiol-dependent deubiquitinase

determination method

13 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92995&geneProductId=UniProtKB:Q92995

determination method

27 March 2018

The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92995&geneProductId=UniProtKB:Q92995

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92995&geneProductId=UniProtKB:Q92995

determination method

27 March 2018

Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92995&geneProductId=UniProtKB:Q92995

determination method

27 March 2018

Regulation of MITF stability by the USP13 deubiquitinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92995&geneProductId=UniProtKB:Q92995

determination method

27 March 2018

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92995&geneProductId=UniProtKB:Q92995

determination method

27 March 2018

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92995&geneProductId=UniProtKB:Q92995

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Regulation of MITF stability by the USP13 deubiquitinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

cysteine-type endopeptidase activity

determination method

3 references

8 April 2019

Deubiquitinating enzymes: a new class of biological regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Regulation of MITF stability by the USP13 deubiquitinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

thiol-dependent deubiquitinase

determination method

7 references

8 April 2019

The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Regulation of MITF stability by the USP13 deubiquitinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Regulation of MITF stability by the USP13 deubiquitinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

positive regulation of ERAD pathway

determination method

1 reference

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

regulation of autophagy

determination method

1 reference

8 April 2019

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

maintenance of unfolded protein involved in ERAD pathway

determination method

1 reference

8 April 2019

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

cell population proliferation

determination method

1 reference

8 April 2019

Regulation of MITF stability by the USP13 deubiquitinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

melanocyte differentiation

determination method

1 reference

8 April 2019

Regulation of MITF stability by the USP13 deubiquitinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

protein K29-linked deubiquitination

determination method

1 reference

8 April 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

protein K6-linked deubiquitination

determination method

1 reference

8 April 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

protein stabilization

determination method

3 references

8 April 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

8 April 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92995

determination method

protein deubiquitination

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Peptidase C19, ubiquitin carboxyl-terminal hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Ubiquitin specific protease domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Zinc finger, UBP-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Ubiquitin specific protease, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Ubiquitin-associated domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92995

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000263966

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000263966

ENSP00000417146

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417146

ENSP00000418651

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418651

ENSP00000420057

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420057

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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