Short chain dehydrogenase/reductase family 16C member 5 (Q21123355)

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mammalian protein found in Homo sapiens

retSDR2
SDR16C5
epidermal retinol dehydrogenase 2
retinal short chain dehydrogenase reductase
retinal short-chain dehydrogenase reductase 2
Short-chain dehydrogenase/reductase family 16C member 5
epidermal retinal dehydrogenase 2

Language	Label	Description	Also known as
English	Short chain dehydrogenase/reductase family 16C member 5	mammalian protein found in Homo sapiens	retSDR2 SDR16C5 epidermal retinol dehydrogenase 2 retinal short chain dehydrogenase reductase retinal short-chain dehydrogenase reductase 2 Short-chain dehydrogenase/reductase family 16C member 5 epidermal retinal dehydrogenase 2

Statements

1 reference

13 November 2019

UniProt protein ID

NAD(P)-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N3Y7

Short-chain dehydrogenase/reductase SDR

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N3Y7

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

oxidoreductase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

NAD-retinol dehydrogenase activity

determination method

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

16 July 2018

Characterization of key residues and membrane association domains in retinol dehydrogenase 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

16 July 2018

Biochemical characterization of human epidermal retinol dehydrogenase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

transcription factor binding

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

DNA-binding transcription factor activity

determination method

1 reference

10 September 2018

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

NAD-retinol dehydrogenase activity

determination method

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

1 January 2018

Biochemical characterization of human epidermal retinol dehydrogenase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

1 January 2018

Characterization of key residues and membrane association domains in retinol dehydrogenase 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

transcription corepressor activity

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

NAD-retinol dehydrogenase activity

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Characterization of key residues and membrane association domains in retinol dehydrogenase 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Biochemical characterization of human epidermal retinol dehydrogenase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

endoplasmic reticulum membrane

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

plasma membrane

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

transcription repressor complex

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

endoplasmic reticulum

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

biological process

retinol metabolic process

determination method

3 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

16 July 2018

Characterization of key residues and membrane association domains in retinol dehydrogenase 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

16 July 2018

Biochemical characterization of human epidermal retinol dehydrogenase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N3Y7&geneProductId=UniProtKB:Q8N3Y7

determination method

keratinocyte proliferation

determination method

1 reference

8 April 2019

Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

positive regulation of histone deacetylation

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

negative regulation of histone acetylation

determination method

1 reference

8 April 2019

A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

retinol metabolic process

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Characterization of key residues and membrane association domains in retinol dehydrogenase 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Biochemical characterization of human epidermal retinol dehydrogenase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

retinal metabolic process

determination method

3 references

8 April 2019

Characterization of key residues and membrane association domains in retinol dehydrogenase 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Biochemical characterization of human epidermal retinol dehydrogenase 2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N3Y7

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000307607

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000307607

ENSP00000379947

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379947

ENSP00000431010

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431010

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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