Nuclear factor, erythroid 2 like 1 (Q21119958)

Nuclear factor erythroid 2-related factor 1/NFE2L1

1 reference

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Basic leucine zipper domain, Maf-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

2 references

transcription coregulator activity

1 reference

8 April 2019

Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

transcription cis-regulatory region binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

protein domain specific binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

27 March 2018

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

27 March 2018

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

27 March 2018

The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

1 reference

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

GOA

curator

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

8 April 2019

A census of human transcription factors: function, expression and evolution

GOA

curator

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

DNA-binding transcription factor activity

ISA

3 references

8 April 2019

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

promoter-specific chromatin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

integral component of endoplasmic reticulum membrane

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of transcription, DNA-templated

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of transcription by RNA polymerase II

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

anatomical structure morphogenesis

IBA

1 reference

8 April 2019

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

heme biosynthetic process

IBA

1 reference

8 April 2019

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

erythrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells

inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

negative regulation of transcription by RNA polymerase II

1 reference

27 March 2018

The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

cellular response to oxidative stress

3 references

27 March 2018

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

positive regulation of transcription from RNA polymerase II promoter in response to stress

3 references

27 March 2018

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

27 March 2018

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter

cell redox homeostasis

2 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

27 March 2018

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

cellular response to cholesterol

1 reference

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

negative regulation of transcription from RNA polymerase II promoter in response to stress

1 reference

27 March 2018

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

regulation of odontoblast differentiation

1 reference

27 March 2018

The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

steroid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

cholesterol metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

cholesterol homeostasis

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14494&geneProductId=UniProtKB:Q14494

transcription by RNA polymerase II

1 reference

8 April 2019

Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

cellular response to oxidative stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

protein polyubiquitination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

fructose 6-phosphate metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

glutathione metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of mitotic nuclear division

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of glucose metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of lipid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of fatty acid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

spinal cord motor neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

glial cell fate commitment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

response to endoplasmic reticulum stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

cholesterol homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

glucose 6-phosphate metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of proteasomal protein catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

cellular response to cold

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

cellular response to cholesterol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of nucleus organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

regulation of response to endoplasmic reticulum stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14494

Basic leucine zipper domain, Maf-type

has part(s)

1 reference

Basic-leucine zipper domain

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

D051265

subject named as

NF-E2-Related Factor 1

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

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1 reference

1 reference