Nudix hydrolase 5 (Q21119621)

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mammalian protein found in Homo sapiens

YSA1H
NUDT5
3.6.1.58
Nucleoside diphosphate-linked moiety X motif 5
nuclear ATP-synthesis protein NUDIX5
8-oxo-dGDP phosphatase
ADP-sugar pyrophosphatase
Nudix motif 5
nudix (nucleoside diphosphate linked moiety X)-type motif 5

Language	Label	Description	Also known as
English	Nudix hydrolase 5	mammalian protein found in Homo sapiens	YSA1H NUDT5 3.6.1.58 Nucleoside diphosphate-linked moiety X motif 5 nuclear ATP-synthesis protein NUDIX5 8-oxo-dGDP phosphatase ADP-sugar pyrophosphatase Nudix motif 5 nudix (nucleoside diphosphate linked moiety X)-type motif 5

Statements

1 reference

13 November 2019

UniProt protein ID

NUDIX hydrolase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKK9

NUDIX hydrolase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NUDIX hydrolase family

1 reference

based on heuristic

inferred from protein domain or family

NUDIX hydrolase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

m7G(5')pppN diphosphatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

magnesium ion binding

determination method

1 reference

8 April 2019

Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

nucleoside-diphosphatase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

ADP-sugar diphosphatase activity

determination method

protein binding

determination method

1 reference

8 April 2019

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

ADP-ribose diphosphatase activity

determination method

4 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKK9&geneProductId=UniProtKB:Q9UKK9

determination method

26 September 2017

Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKK9&geneProductId=UniProtKB:Q9UKK9

determination method

26 September 2017

Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKK9&geneProductId=UniProtKB:Q9UKK9

determination method

26 September 2017

Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKK9&geneProductId=UniProtKB:Q9UKK9

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

nucleotidyltransferase activity

determination method

1 reference

8 April 2019

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

ADP-ribose diphosphatase activity

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

intracellular anatomical structure

determination method

1 reference

1 January 2018

Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKK9&geneProductId=UniProtKB:Q9UKK9

determination method

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKK9&geneProductId=UniProtKB:Q9UKK9

determination method

26 September 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKK9&geneProductId=UniProtKB:Q9UKK9

determination method

26 September 2017

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKK9&geneProductId=UniProtKB:Q9UKK9

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

biological process

nucleobase-containing small molecule catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

ribonucleoside diphosphate catabolic process

determination method

4 references

8 April 2019

Cloning and characterization of a new member of the Nudix hydrolases from human and mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

8 April 2019

Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

nucleobase-containing compound metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

nucleotide metabolic process

determination method

1 reference

8 April 2019

Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

D-ribose catabolic process

determination method

chromatin remodeling

determination method

1 reference

8 April 2019

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

ATP generation from poly-ADP-D-ribose

determination method

1 reference

8 April 2019

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

nucleoside phosphate metabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

ribose phosphate metabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKK9

determination method

EC enzyme number

3.6.1.58

1 reference

14 November 2015

http://www.uniprot.org/uniprot/Q9UKK9.txt?version=141

NUDIX hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKK9

NUDIX hydrolase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKK9

NUDIX hydrolase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKK9

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000419628

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419628

ENSP00000445116

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445116

ENSP00000368209

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368209

ENSP00000368219

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368219

ENSP00000368222

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368222

ENSP00000407856

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407856

ENSP00000436844

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000436844

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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