Nuclear factor kappa B subunit 2 (Q21119374)

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mammalian protein found in Homo sapiens

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
oncogene Lyt-10
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
DNA-binding factor KBF2
lymphocyte translocation chromosome 10 protein
Lyt10
nuclear factor of Kappa light chain gene enhancer in B cells 2
transcription factor NFKB2
nuclear factor Kappa-B, subunit 2
nuclear factor NF-kappa-B p100 subunit
NFKB2
NFKB, p52/p100 subunit
H2TF1
nuclear factor NF-kappa-B p52 subunit

Language	Label	Description	Also known as
English	Nuclear factor kappa B subunit 2	mammalian protein found in Homo sapiens	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) oncogene Lyt-10 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 DNA-binding factor KBF2 lymphocyte translocation chromosome 10 protein Lyt10 nuclear factor of Kappa light chain gene enhancer in B cells 2 transcription factor NFKB2 nuclear factor Kappa-B, subunit 2 nuclear factor NF-kappa-B p100 subunit NFKB2 NFKB, p52/p100 subunit H2TF1 nuclear factor NF-kappa-B p52 subunit

Statements

1 reference

13 November 2019

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Rel homology domain (RHD), DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

NF-kappa-B/Dorsal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Immunoglobulin E-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

IPT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology domain (RHD), DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NFkappaB IPT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

2 references

DNA-binding transcription factor activity

determination method

3 references

8 April 2019

Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

chromatin binding

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

NF- kappa B2/p100 induces Bcl-2 expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

protein binding

determination method

9 references

8 April 2019

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

determination method

3 references

Bcl3/NF-kappaB2 complex

determination method

1 reference

8 April 2019

Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

8 April 2019

NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

determination method

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

27 March 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

biological process

rhythmic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

germinal center formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

extracellular matrix organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

spleen development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

follicular dendritic cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

response to lipopolysaccharide

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

NIK/NF-kappaB signaling

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

inflammatory response

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

positive regulation of type I interferon production

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

NF- kappa B2/p100 induces Bcl-2 expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

innate immune response

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00653&geneProductId=UniProtKB:Q00653

determination method

response to cytokine

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00653

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Rel homology dimerisation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

ankyrin repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Rel homology domain, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Rel homology domain (RHD), DNA-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

NFkappaB IPT domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00653

Identifiers

MeSH descriptor ID

subject named as

NF-kappa B p52 Subunit

0 references

D12.776.157.687.497

0 references

D12.776.260.600.186

0 references

D12.776.660.600.186

0 references

D12.776.660.720.497

0 references

D12.776.930.600.186

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000189444

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000189444

ENSP00000358983

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000358983

ENSP00000410256

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000410256

ENSP00000470826

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470826

ENSP00000498308

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498308

ENSP00000499294

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000499294

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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