TXK tyrosine kinase (Q21119231)

Protein kinase-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

SH2 domain, protein family

1 reference

Tyrosine-protein kinase TXK, SH3 domain, protein family

1 reference

Tyrosine-protein kinase TXK, SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

protein kinase activity

1 reference

8 April 2019

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

10 September 2018

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

8 April 2019

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

2 references

8 April 2019

Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

8 April 2019

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

signaling receptor binding

IPI

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

2 references

non-membrane spanning protein tyrosine kinase activity

3 references

10 September 2018

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

8 April 2019

Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

8 April 2019

Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

extrinsic component of cytoplasmic side of plasma membrane

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

8 April 2019

Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

8 April 2019

Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

regulation of transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

immune system process

1 reference

8 April 2019

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

positive regulation of interferon-gamma-mediated signaling pathway

ISS

1 reference

8 April 2019

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

positive regulation of interferon-gamma production

2 references

8 April 2019

Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

8 April 2019

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

activation of phospholipase C activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

transcription, DNA-templated

ISS

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

protein phosphorylation

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

10 September 2018

Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

regulation of cell population proliferation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

peptidyl-tyrosine autophosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

integrin-mediated signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

protein autophosphorylation

regulation of platelet activation

2 references

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

T cell receptor signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

positive regulation of transcription by RNA polymerase II

ISS

1 reference

8 April 2019

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

transcription by RNA polymerase II

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P42681&geneProductId=UniProtKB:P42681

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

adaptive immune response

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42681

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5710

language of work or name

English

retrieved

17 August 2016

has part(s)

tyrosine-protein kinase, active site

1 reference

SH3 domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

SH2 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Tyrosine-protein kinase TXK, SH3 domain

1 reference

Tyrosine-protein kinase TXK, SH2 domain

1 reference