Glycoprotein Ib platelet subunit alpha (Q21118963)

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mammalian protein found in Homo sapiens

GP1BA
platelet glycoprotein Ib alpha chain
glycoprotein Ib (platelet), alpha polypeptide
platelet membrane glycoprotein Ib-alpha
antigen CD42b-alpha
mutant platelet membrane glycoprotein Ib-alpha
glycoprotein Ib platelet alpha subunit
GP-Ib alpha
platelet membrane glycoprotein 1b-alpha subunit

Language	Label	Description	Also known as
English	Glycoprotein Ib platelet subunit alpha	mammalian protein found in Homo sapiens	GP1BA platelet glycoprotein Ib alpha chain glycoprotein Ib (platelet), alpha polypeptide platelet membrane glycoprotein Ib-alpha antigen CD42b-alpha mutant platelet membrane glycoprotein Ib-alpha glycoprotein Ib platelet alpha subunit GP-Ib alpha platelet membrane glycoprotein 1b-alpha subunit

Statements

1 reference

13 November 2019

UniProt protein ID

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P07359

Leucine-rich repeat N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein kinase inhibitor activity

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

thrombin-activated receptor activity

determination method

protein binding

determination method

10 references

8 April 2019

A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Juxtamembrane basic residues in glycoprotein Ibbeta cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Nbeal2 interacts with Dock7, Sec16a, and Vac14.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

plasma membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

determination method

1 reference

26 September 2017

Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

extracellular exosome

determination method

1 reference

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

extracellular space

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

determination method

1 reference

8 April 2019

Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

extracellular matrix

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

anchored component of external side of plasma membrane

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

biological process

blood coagulation, intrinsic pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

determination method

1 reference

8 April 2019

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

negative regulation of protein kinase activity

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

cytokine-mediated signaling pathway

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

blood coagulation

determination method

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

26 September 2017

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

cell surface receptor signaling pathway

determination method

1 reference

8 April 2019

The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

determination method

3 references

26 September 2017

Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

26 September 2017

Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

cell morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

regulation of blood coagulation

determination method

1 reference

8 April 2019

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

negative regulation of receptor signaling pathway via JAK-STAT

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

thrombin-activated receptor signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

platelet aggregation

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07359&geneProductId=UniProtKB:P07359

determination method

regulation of megakaryocyte differentiation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

determination method

4 references

8 April 2019

Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

blood coagulation

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07359

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000329380

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000329380

ENSP00000484439

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484439

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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