DNA replication helicase/nuclease 2 (Q21117504)

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mammalian protein found in Homo sapiens

DNA replication ATP-dependent helicase-like homolog
DNA2 DNA replication helicase 2-like
DNA2-like helicase
DNA2
DNA replication helicase 2 homolog
DNA replication ATP-dependent helicase/nuclease DNA2

Language	Label	Description	Also known as
English	DNA replication helicase/nuclease 2	mammalian protein found in Homo sapiens	DNA replication ATP-dependent helicase-like homolog DNA2 DNA replication helicase 2-like DNA2-like helicase DNA2 DNA replication helicase 2 homolog DNA replication ATP-dependent helicase/nuclease DNA2

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51530

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51530

DNA replication factor Dna2, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

4 iron, 4 sulfur cluster binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

iron-sulfur cluster binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

5'-flap endonuclease activity

determination method

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

24 April 2018

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

24 April 2018

Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

24 April 2018

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

24 April 2018

Isolation of human Dna2 endonuclease and characterization of its enzymatic properties

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

24 April 2018

Biochemical analysis of human Dna2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

ATPase activity

determination method

1 reference

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

protein binding

determination method

catalytic activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

5'-3' DNA helicase activity

determination method

1 reference

8 April 2019

Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

endonuclease activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

site-specific endodeoxyribonuclease activity, specific for altered base

determination method

1 reference

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

single-stranded DNA helicase activity

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Biochemical analysis of human Dna2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Isolation of human Dna2 endonuclease and characterization of its enzymatic properties

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

5'-flap endonuclease activity

determination method

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Isolation of human Dna2 endonuclease and characterization of its enzymatic properties

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Biochemical analysis of human Dna2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

gamma DNA polymerase complex

determination method

1 reference

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

mitochondrial nucleoid

determination method

1 reference

8 April 2019

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

determination method

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

24 April 2018

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

24 April 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51530&geneProductId=UniProtKB:P51530

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

biological process

mitochondrial DNA repair

determination method

1 reference

8 April 2019

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

DNA double-strand break processing

determination method

1 reference

8 April 2019

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

DNA replication checkpoint signaling

determination method

1 reference

8 April 2019

Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

positive regulation of DNA replication

determination method

1 reference

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

base-excision repair

determination method

1 reference

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

DNA replication, removal of RNA primer

determination method

1 reference

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

DNA replication

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

DNA duplex unwinding

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

G-quadruplex DNA unwinding

determination method

1 reference

8 April 2019

A balance between elongation and trimming regulates telomere stability in stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

t-circle formation

determination method

1 reference

8 April 2019

A balance between elongation and trimming regulates telomere stability in stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

telomere maintenance via semi-conservative replication

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

replication fork reversal

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

regulation of signal transduction by p53 class mediator

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51530

determination method

http://purl.uniprot.org/uniprot/P51530

1 reference

Identifiers.org

DNA replication factor Dna2, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51530

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000351185

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000351185

ENSP00000382132

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000382132

ENSP00000382133

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000382133

ENSP00000389713

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389713

ENSP00000450014

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450014

ENSP00000450393

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450393

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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