Forkhead box C1 (Q21116910)

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mammalian protein found in Homo sapiens
  • forkhead/winged helix-like transcription factor 7
  • FOXC1
  • forkhead box C1 protein
  • forkhead, drosophila, homolog-like 7
  • forkhead-related protein FKHL7
  • forkhead-related activator 3
  • FREAC-3
  • forkhead box protein C1
  • forkhead-related transcription factor 3
  • myeloid factor-delta
edit
Language Label Description Also known as
English
Forkhead box C1
mammalian protein found in Homo sapiens
  • forkhead/winged helix-like transcription factor 7
  • FOXC1
  • forkhead box C1 protein
  • forkhead, drosophila, homolog-like 7
  • forkhead-related protein FKHL7
  • forkhead-related activator 3
  • FREAC-3
  • forkhead box protein C1
  • forkhead-related transcription factor 3
  • myeloid factor-delta

Statements

molecular function
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IPI
retrieved
8 April 2019
stated in
Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IPI
retrieved
8 April 2019
stated in
FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IPI
retrieved
8 April 2019
stated in
Global landscape of HIV-human protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IPI
retrieved
8 April 2019
stated in
Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 transcriptional activity in ocular cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IPI
retrieved
8 April 2019
stated in
Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IPI
DNA-binding transcription factor activity
determination method
IDA
IEA
IMP
16 references
retrieved
8 April 2019
stated in
Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Analyses of a novel L130F missense mutation in FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Identification and Analysis of a Novel Mutation in the FOXC1 Forkhead Domain
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IEA
retrieved
8 April 2019
stated in
FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Essential structural and functional determinants within the forkhead domain of FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Identification and Analysis of a Novel Mutation in the FOXC1 Forkhead Domain
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
cell component
nucleus
determination method
IC
IDA
IEA
18 references
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IEA
retrieved
27 March 2018
stated in
Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Identification and Analysis of a Novel Mutation in the FOXC1 Forkhead Domain
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Analyses of a novel L130F missense mutation in FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Essential structural and functional determinants within the forkhead domain of FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
27 March 2018
stated in
Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12948&geneProductId=UniProtKB:Q12948
determination method
IC
nucleus
determination method
IBA
IC
IDA
IEA
19 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IEA
retrieved
8 April 2019
stated in
Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Analyses of a novel L130F missense mutation in FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Essential structural and functional determinants within the forkhead domain of FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Identification and Analysis of a Novel Mutation in the FOXC1 Forkhead Domain
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IEA
IMP
ISS
12 references
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
ISS
retrieved
8 April 2019
stated in
Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Analyses of a novel L130F missense mutation in FOXC1
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Characterization of a novel FOXC1 mutation, P297S, identified in two individuals with anterior segment dysgenesis
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Hypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variability
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
Identification and Analysis of a Novel Mutation in the FOXC1 Forkhead Domain
GOA
curator
UniProt
UniProt protein ID
Q12948
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IEA
retrieved
8 April 2019
stated in
FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA
retrieved
8 April 2019
stated in
Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12948
determination method
IDA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21116910&oldid=2022968079"