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GRB2 associated binding protein 1 (Q21116882)

From Wikidata
mammalian protein found in Homo sapiens
  • symbol withdrawn, see GAB1
  • GAB1
  • deafness, autosomal recessive 26
  • GRB2-associated-binding protein 1
  • growth factor receptor bound protein 2-associated protein 1
  • GRB2-associated binder 1
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    English
    GRB2 associated binding protein 1
    mammalian protein found in Homo sapiens
    • symbol withdrawn, see GAB1
    • GAB1
    • deafness, autosomal recessive 26
    • GRB2-associated-binding protein 1
    • growth factor receptor bound protein 2-associated protein 1
    • GRB2-associated binder 1

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    22 references
    retrieved
    8 April 2019
    stated in
    Modifier variant of METTL13 suppresses human GAB1-associated profound deafness
    GOA
    curator
    UniProt
    UniProt protein ID
    Q13480
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human MAP kinase interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Large-scale structural analysis of the classical human protein tyrosine phosphatome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Charting the molecular network of the drug target Bcr-Abl
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Co-clustering of Fcgamma and B cell receptors induces dephosphorylation of the Grb2-associated binder 1 docking protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13480
    determination method or standard
    IPI
    biological process

    Identifiers

     
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