Beta-transducin repeat containing E3 ubiquitin protein ligase (Q21116841)

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mammalian protein found in Homo sapiens
  • BTRC
  • F-box and WD repeats protein beta-TrCP
  • beta-TrCP1
  • E3RSIkappaB
  • epididymis tissue protein Li 2a
  • pIkappaBalpha-E3 receptor subunit
  • F-box and WD-repeat protein 1B
  • F-box/WD repeat-containing protein 1A
edit
Language Label Description Also known as
English
Beta-transducin repeat containing E3 ubiquitin protein ligase
mammalian protein found in Homo sapiens
  • BTRC
  • F-box and WD repeats protein beta-TrCP
  • beta-TrCP1
  • E3RSIkappaB
  • epididymis tissue protein Li 2a
  • pIkappaBalpha-E3 receptor subunit
  • F-box and WD-repeat protein 1B
  • F-box/WD repeat-containing protein 1A

Statements

molecular function
protein binding
determination method
IPI
48 references
retrieved
8 April 2019
stated in
Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Defining the human deubiquitinating enzyme interaction landscape
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Array MAPPIT: high-throughput interactome analysis in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
TIP120A associates with cullins and modulates ubiquitin ligase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
retrieved
8 April 2019
stated in
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y297
determination method
IPI
ubiquitin-protein transferase activity
determination method
EXP
TAS
IDA
5 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y297&geneProductId=UniProtKB:Q9Y297
determination method
TAS
retrieved
1 January 2018
stated in
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
GOA
curator
UniProt
UniProt protein ID
Q9Y297
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y297&geneProductId=UniProtKB:Q9Y297
determination method
IDA
retrieved
1 January 2018
stated in
Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y297&geneProductId=UniProtKB:Q9Y297
determination method
EXP
retrieved
1 January 2018
stated in
Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y297&geneProductId=UniProtKB:Q9Y297
determination method
EXP
retrieved
1 January 2018
stated in
Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y297&geneProductId=UniProtKB:Q9Y297
determination method
EXP
cell component
biological process

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21116841&oldid=2022967854"