Ubiquilin 4 (Q21116430)

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mammalian protein found in Homo sapiens

connexin43-interacting protein of 75 kDa
CIP75
UBQLN4
ataxin-1 interacting ubiquitin-like protein
ataxin-1 ubiquitin-like interacting protein
ubiquilin-4
ataxin-1 ubiquitin-like-interacting protein A1U
A1Up

Language	Label	Description	Also known as
English	Ubiquilin 4	mammalian protein found in Homo sapiens	connexin43-interacting protein of 75 kDa CIP75 UBQLN4 ataxin-1 interacting ubiquitin-like protein ataxin-1 ubiquitin-like interacting protein ubiquilin-4 ataxin-1 ubiquitin-like-interacting protein A1U A1Up

Statements

1 reference

13 November 2019

UniProt protein ID

UBA-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRR5

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRR5

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Ubiquitin-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Heat shock chaperonin-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

polyubiquitin modification-dependent protein binding

determination method

1 reference

7 November 2018

The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NRR5&geneProductId=UniProtKB:Q9NRR5

determination method

protein binding

determination method

9 references

9 May 2019

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Herp enhances ER-associated protein degradation by recruiting ubiquilins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Ubiquitin-independent Proteasomal Degradation of Endoplasmic Reticulum-localized Connexin43 Mediated by CIP75

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

identical protein binding

determination method

3 references

9 May 2019

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

polyubiquitin modification-dependent protein binding

determination method

3 references

9 May 2019

The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

perinuclear region of cytoplasm

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

nuclear proteasome complex

determination method

1 reference

9 May 2019

The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

cytosolic proteasome complex

determination method

1 reference

7 November 2018

The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NRR5&geneProductId=UniProtKB:Q9NRR5

determination method

cytoplasmic vesicle

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

determination method

3 references

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

site of DNA damage

determination method

1 reference

9 May 2019

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

biological process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

negative regulation of autophagosome maturation

determination method

1 reference

9 May 2019

Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

1 January 2018

The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

negative regulation of double-strand break repair via homologous recombination

determination method

1 reference

9 May 2019

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NRR5

determination method

Ubiquitin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRR5

Heat shock chaperonin-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRR5

Ubiquitin-associated domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NRR5

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000357292

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000357292

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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