Glutamate ionotropic receptor NMDA type subunit 2B (Q21115816)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13224

ionotropic glutamate receptor, metazoa

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13224

NMDA receptor

0 references

Receptor, ligand binding region, protein family

1 reference

Ionotropic glutamate receptor domain, protein family

1 reference

Glutamate [NMDA] receptor, epsilon subunit, C-terminal domain, protein family

1 reference

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 references

8 April 2019

Analysis of NR3A receptor subunits in human native NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Proteome-wide analysis of phospho-regulated PDZ domain interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

ionotropic glutamate receptor activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

extracellularly glutamate-gated ion channel activity

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

NMDA glutamate receptor activity

3 references

31 October 2017

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

31 October 2017

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

glutamate-gated calcium ion channel activity

1 reference

8 April 2019

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

NMDA glutamate receptor activity

5 references

8 April 2019

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

postsynaptic membrane

1 reference

31 October 2017

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

NMDA selective glutamate receptor complex

4 references

31 October 2017

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

31 October 2017

Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

31 October 2017

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

31 October 2017

Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

intracellular anatomical structure

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

integral component of plasma membrane

3 references

8 April 2019

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

3 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

31 October 2017

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

NMDA selective glutamate receptor complex

6 references

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

postsynaptic density membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

glutamate receptor signaling pathway

biological process

1 reference

8 April 2019

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

ephrin receptor signaling pathway

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

1 reference

31 October 2017

Genetic enhancement of learning and memory in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

Enhanced ethanol inhibition of recombinant N-methyl-D-aspartate receptors by magnesium: role of NR3A subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

chemical synaptic transmission

IDA

1 reference

8 April 2019

Genetic enhancement of learning and memory in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

ionotropic glutamate receptor signaling pathway

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

excitatory postsynaptic potential

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

regulation of ion transmembrane transport

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

calcium-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

protein heterotetramerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

regulation of molecular function

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13224&geneProductId=UniProtKB:Q13224

calcium ion transmembrane import into cytosol

multicellular organism development

IDA

IMP

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

regulation of synaptic plasticity

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

excitatory postsynaptic potential

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

long-term potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

excitatory chemical synaptic transmission

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

positive regulation of neuron death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

negative regulation of dendritic spine maintenance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

positive regulation of cysteine-type endopeptidase activity

1 reference

8 April 2019

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

regulation of NMDA receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13224

physically interacts with

TAS

1 reference

727

17 August 2016

1 reference

3309

17 August 2016

1 reference

4216

17 August 2016

1 reference

4068

English

17 August 2016

N-methyl-D-aspartic acid

has use

agonist

1 reference

4268

English

5,7-dichlorokynurenic acid

17 August 2016

has use

antagonist

1 reference

2361

17 August 2016

1 reference

4170

17 August 2016

1 reference

4155

17 August 2016

1 reference

4128

17 August 2016

1 reference

2403

17 August 2016

1 reference

4233

17 August 2016

1 reference

4282

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL467084

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2068839

neboglamine

positive allosteric modullator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1255840

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107771

esketamine

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL395091

ketamine

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL742

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL41306

ketamine hydrochloride

negative allosteric modulator

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1714

amantadine hydrochloride

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1569

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200395

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

1.A.10.1.6

1 reference