NIMA related kinase 6 (Q21115285)

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mammalian protein found in Homo sapiens

nimA-related protein kinase 6
NEK6
protein kinase SID6-1512
serine/threonine-protein kinase Nek6
NIMA (never in mitosis gene a)-related kinase 6
never in mitosis A-related kinase 6
putative serine-threonine protein kinase

Language	Label	Description	Also known as
English	NIMA related kinase 6	mammalian protein found in Homo sapiens	nimA-related protein kinase 6 NEK6 protein kinase SID6-1512 serine/threonine-protein kinase Nek6 NIMA (never in mitosis gene a)-related kinase 6 never in mitosis A-related kinase 6 putative serine-threonine protein kinase

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9HC98

animal nuclear pore complex

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

nucleotide binding

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

protein kinase activity

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

signal transducer activity

determination method

1 reference

26 September 2017

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

metal ion binding

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

kinase activity

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

protein binding

determination method

3 references

26 September 2017

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

kinesin binding

determination method

1 reference

26 September 2017

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

protein kinase binding

determination method

1 reference

26 September 2017

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

magnesium ion binding

determination method

1 reference

26 September 2017

The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

protein serine/threonine kinase activity

determination method

5 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

transcription corepressor binding

determination method

1 reference

26 September 2017

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

ubiquitin protein ligase binding

determination method

1 reference

26 September 2017

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

intracellular membrane-bounded organelle

determination method

1 reference

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

1 reference

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

2 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

1 reference

26 September 2017

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

biological process

phosphorylation

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

spindle assembly

determination method

1 reference

26 September 2017

A role for Nek6 kinase activity in preventing senescence?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

mitotic nuclear membrane disassembly

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

peptidyl-serine phosphorylation

determination method

1 reference

26 September 2017

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

regulation of mitotic cell cycle

determination method

1 reference

26 September 2017

Caught Nek-ing: cilia and centrioles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

regulation of mitotic metaphase/anaphase transition

determination method

1 reference

26 September 2017

The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

26 September 2017

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

protein autophosphorylation

determination method

regulation of cellular senescence

determination method

1 reference

26 September 2017

A role for Nek6 kinase activity in preventing senescence?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

apoptotic process

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

signal transduction

determination method

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC98&geneProductId=UniProtKB:Q9HC98

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000319734

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000319734

ENSP00000362702

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362702

ENSP00000362705

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362705

ENSP00000377749

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377749

ENSP00000439651

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000439651

ENSP00000441426

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441426

ENSP00000441469

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441469

ENSP00000442636

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442636

ENSP00000362698

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362698

ENSP00000389517

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389517

ENSP00000399847

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399847

ENSP00000403087

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403087

ENSP00000403414

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403414

ENSP00000405215

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405215

ENSP00000411401

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411401

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Multilingual sites(0 entries)

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