Nudix hydrolase 1 (Q21115125)

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mammalian protein found in Homo sapiens

nucleoside diphosphate-linked moiety X-type motif 1
NUDT1
mutT human homolog 1
7,8-dihydro-8-oxoguanine triphosphatase
nudix (nucleoside diphosphate linked moiety X)-type motif 1
8-oxo-7,8-dihydroguanosine triphosphatase
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
8-oxo-dGTPase
3.6.1.56
nudix motif 1
nucleoside diphosphate-linked moiety X motif 1
2-hydroxy-dATP diphosphatase

Language	Label	Description	Also known as
English	Nudix hydrolase 1	mammalian protein found in Homo sapiens	nucleoside diphosphate-linked moiety X-type motif 1 NUDT1 mutT human homolog 1 7,8-dihydro-8-oxoguanine triphosphatase nudix (nucleoside diphosphate linked moiety X)-type motif 1 8-oxo-7,8-dihydroguanosine triphosphatase 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase 8-oxo-dGTPase 3.6.1.56 nudix motif 1 nucleoside diphosphate-linked moiety X motif 1 2-hydroxy-dATP diphosphatase

Statements

1 reference

13 November 2019

UniProt protein ID

NUDIX hydrolase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36639

7,8-dihydro-8-oxoguanine triphosphatase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36639

NUDIX hydrolase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NUDIX hydrolase family

1 reference

based on heuristic

inferred from protein domain or family

NUDIX hydrolase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

m7G(5')pppN diphosphatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

protein binding

determination method

1 reference

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

GTP diphosphatase activity

determination method

1 reference

8 April 2019

Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

determination method

4 references

5 June 2018

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36639&geneProductId=UniProtKB:P36639

determination method

5 June 2018

Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36639&geneProductId=UniProtKB:P36639

determination method

5 June 2018

Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36639&geneProductId=UniProtKB:P36639

determination method

5 June 2018

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36639&geneProductId=UniProtKB:P36639

determination method

8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

nuclear membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

plasma membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

acrosomal vesicle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

extracellular space

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

biological process

nucleobase-containing small molecule catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

dATP catabolic process

determination method

1 reference

8 April 2019

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

purine nucleotide catabolic process

determination method

1 reference

8 April 2019

Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

determination method

1 reference

8 April 2019

Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

response to oxidative stress

determination method

1 reference

8 April 2019

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

dGTP catabolic process

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

8 April 2019

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

response to cadmium ion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

male gonad development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36639

determination method

EC enzyme number

3.6.1.56

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P36639.txt?version=154

NUDIX hydrolase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36639

NUDIX hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36639

NUDIX hydrolase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36639

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000339503

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000339503

ENSP00000343439

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000343439

ENSP00000349148

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349148

ENSP00000380239

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380239

ENSP00000380241

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380241

ENSP00000380242

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380242

ENSP00000405334

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000405334

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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