Serine peptidase inhibitor Kazal type 5 (Q21114782)

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mammalian protein found in Homo sapiens

lympho-epithelial Kazal-type-related inhibitor
lymphoepithelial Kazal-type-related inhibitor
serine protease inhibitor Kazal-type 5
SPINK5
LEKTI
Serine Peptidase Inhibitor Kazal-Type 5

Language	Label	Description	Also known as
English	Serine peptidase inhibitor Kazal type 5	mammalian protein found in Homo sapiens	lympho-epithelial Kazal-type-related inhibitor lymphoepithelial Kazal-type-related inhibitor serine protease inhibitor Kazal-type 5 SPINK5 LEKTI Serine Peptidase Inhibitor Kazal-Type 5

Statements

1 reference

13 November 2019

UniProt protein ID

Kazal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NQ38

Kazal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

serine-type endopeptidase inhibitor activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

8 April 2019

Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

8 April 2019

LEKTI, a novel 15-domain type of human serine proteinase inhibitor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

determination method

1 reference

8 April 2019

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

determination method

1 reference

8 April 2019

Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

determination method

1 reference

8 April 2019

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

epidermal lamellar body

determination method

1 reference

8 April 2019

LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

extracellular region

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

8 April 2019

LEKTI, a novel 15-domain type of human serine proteinase inhibitor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

8 April 2019

Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

biological process

epidermal cell differentiation

determination method

1 reference

8 April 2019

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

negative regulation of proteolysis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

negative regulation of serine-type peptidase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

negative regulation of peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

epithelial cell differentiation

determination method

1 reference

8 April 2019

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

hair cell differentiation

determination method

1 reference

8 April 2019

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

extracellular matrix organization

determination method

1 reference

8 April 2019

Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

negative regulation of antibacterial peptide production

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

negative regulation of immune response

determination method

1 reference

8 April 2019

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

regulation of cell adhesion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

negative regulation of angiogenesis

determination method

1 reference

8 April 2019

Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

negative regulation of serine-type endopeptidase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

regulation of T cell differentiation

determination method

1 reference

8 April 2019

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

regulation of timing of anagen

determination method

1 reference

8 April 2019

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ38

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9NQ38

Identifiers

MeSH descriptor ID

subject named as

Serine Peptidase Inhibitor Kazal-Type 5

0 references

D12.644.822.750.250

0 references

D12.776.645.688.250

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000256084

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000256084

ENSP00000352936

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352936

ENSP00000381472

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381472

ENSP00000421519

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421519

ENSP00000427943

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427943

ENSP00000430264

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430264

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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