Protein phosphatase 1 regulatory subunit 15A (Q21114212)

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mammalian protein found in Homo sapiens

myeloid differentiation primary response protein MyD116 homolog
growth arrest and DNA damage-inducible protein GADD34
growth arrest and DNA-damage-inducible 34
protein phosphatase 1, regulatory (inhibitor) subunit 15A
protein phosphatase 1 regulatory subunit 15A
PPP1R15A

Language	Label	Description	Also known as
English	Protein phosphatase 1 regulatory subunit 15A	mammalian protein found in Homo sapiens	myeloid differentiation primary response protein MyD116 homolog growth arrest and DNA damage-inducible protein GADD34 growth arrest and DNA-damage-inducible 34 protein phosphatase 1, regulatory (inhibitor) subunit 15A protein phosphatase 1 regulatory subunit 15A PPP1R15A

Statements

1 reference

13 November 2019

UniProt protein ID

Protein phosphatase 1, regulatory subunit 15A/B, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

4 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Functional proteomics mapping of a human signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

protein phosphatase 1 binding

determination method

3 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

protein phosphatase activator activity

determination method

1 reference

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

protein phosphatase regulator activity

determination method

2 references

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

protein phosphatase regulator activity

determination method

3 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

mitochondrial outer membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

protein phosphatase type 1 complex

determination method

2 references

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

endoplasmic reticulum

determination method

3 references

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

5 June 2018

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

determination method

1 reference

5 June 2018

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

protein phosphatase type 1 complex

determination method

3 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

endoplasmic reticulum

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

biological process

negative regulation of protein dephosphorylation

determination method

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

Mammalian GADD34, an apoptosis- and DNA damage-inducible gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation

determination method

positive regulation of translational initiation in response to stress

determination method

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

positive regulation of phosphoprotein phosphatase activity

determination method

1 reference

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

determination method

1 reference

8 April 2019

The endoplasmic reticulum stress response in aging and age-related diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

negative regulation of phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

protein localization to endoplasmic reticulum

determination method

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

regulation of translational initiation by eIF2 alpha dephosphorylation

determination method

1 reference

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

negative regulation of PERK-mediated unfolded protein response

determination method

1 reference

8 April 2019

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

regulation of translation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

response to endoplasmic reticulum stress

determination method

1 reference

5 June 2018

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75807&geneProductId=UniProtKB:O75807

determination method

positive regulation of peptidyl-serine dephosphorylation

determination method

3 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

positive regulation of phosphoprotein phosphatase activity

determination method

response to endoplasmic reticulum stress

determination method

2 references

8 April 2019

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75807

determination method

Protein phosphatase 1, regulatory subunit 15A/B, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75807

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000200453

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000200453

ENSP00000469239

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469239

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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