T cell immunoreceptor with Ig and ITIM domains (Q21114021)

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mammalian protein found in Homo sapiens

• TIGIT
• VSIG9, VSTM3
• T-cell immunoreceptor with Ig and ITIM domains
• V-set and transmembrane domain containing 3
• V-set and immunoglobulin domain-containing protein 9
• V-set and immunoglobulin domain containing 9
• V-set and transmembrane domain-containing protein 3
• Washington University cell adhesion molecule
• TIGIT protein, human

edit

Language	Label	Description	Also known as
English	T cell immunoreceptor with Ig and ITIM domains	mammalian protein found in Homo sapiens	TIGIT VSIG9, VSTM3 T-cell immunoreceptor with Ig and ITIM domains V-set and transmembrane domain containing 3 V-set and immunoglobulin domain-containing protein 9 V-set and immunoglobulin domain containing 9 V-set and transmembrane domain-containing protein 3 Washington University cell adhesion molecule TIGIT protein, human

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q495A1

part of

Immunoglobulin-like fold

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q495A1

Immunoglobulin-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q495A1

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

TIGIT.png
1,920 × 975; 286 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q495A1

encoded by

TIGIT

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q495A1

molecular function

signaling receptor binding

determination method

IPI

1 reference

retrieved

27 March 2018

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IPI

protein binding

determination method

IPI

5 references

retrieved

8 April 2019

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IPI

retrieved

8 April 2019

stated in

A secreted protein microarray platform for extracellular protein interaction discovery

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IPI

retrieved

8 April 2019

stated in

Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IPI

retrieved

8 April 2019

stated in

Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT).

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IPI

retrieved

8 April 2019

stated in

The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IPI

protein homodimerization activity

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IBA

cell adhesion molecule binding

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IBA

identical protein binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IPI

signaling receptor binding

determination method

IBA

IPI

2 references

retrieved

8 April 2019

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IPI

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IBA

identical protein binding

determination method

IBA

IPI

2 references

retrieved

1 January 2018

stated in

Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IPI

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IBA

cell component

integral component of membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IEA

cell surface

determination method

IDA

2 references

retrieved

27 March 2018

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IDA

retrieved

27 March 2018

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IDA

plasma membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IEA

integral component of plasma membrane

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IBA

membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IEA

cell surface

determination method

IBA

IDA

3 references

retrieved

8 April 2019

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IDA

retrieved

8 April 2019

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IBA

biological process

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IBA

cell recognition

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IBA

negative regulation of T cell activation

determination method

IDA

IMP

2 references

retrieved

27 March 2018

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IMP

retrieved

27 March 2018

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IDA

positive regulation of interleukin-10 production

determination method

IMP

1 reference

retrieved

27 March 2018

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IMP

homophilic cell adhesion via plasma membrane adhesion molecules

determination method

IBA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IBA

negative regulation of interleukin-12 production

determination method

IMP

1 reference

retrieved

27 March 2018

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q495A1&geneProductId=UniProtKB:Q495A1

determination method

IMP

negative regulation of interleukin-12 production

determination method

IBA

IMP

2 references

retrieved

8 April 2019

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IMP

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IBA

positive regulation of interleukin-10 production

determination method

IBA

IMP

2 references

retrieved

8 April 2019

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IMP

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IBA

negative regulation of T cell activation

determination method

IBA

IDA

IMP

3 references

retrieved

8 April 2019

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

UniProt

UniProt protein ID

Q495A1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IMP

retrieved

8 April 2019

stated in

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q495A1

determination method

IBA

has part(s)

immunoglobulin V-set domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q495A1

immunoglobulin-like domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q495A1

immunoglobulin subtype

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q495A1

Identifiers

MeSH descriptor ID

C534712

subject named as

TIGIT protein, human

0 references

RefSeq protein ID

NP_776160

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

201633

XP_024309156

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

201633

UniProt protein ID

Q495A1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q495A1

Ensembl protein ID

ENSP00000373167

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000373167

ENSP00000419085

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000419085

ENSP00000418917

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000418917

ENSP00000419706

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000419706

ENSP00000420552

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000420552

Freebase ID

/m/0h_djqb

0 references

Microsoft Academic ID

2779118045

0 references

OpenAlex ID

C2779118045

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

3Q0H

1 reference

stated in

UniProt

UniProt protein ID

Q495A1

retrieved

30 June 2016

language of work or name

English

3RQ3

1 reference

stated in

UniProt

UniProt protein ID

Q495A1

retrieved

30 June 2016

language of work or name

English

3UCR

1 reference

stated in

UniProt

UniProt protein ID

Q495A1

retrieved

30 June 2016

language of work or name

English

3UDW

1 reference

stated in

UniProt

UniProt protein ID

Q495A1

retrieved

30 June 2016

language of work or name

English

UMLS CUI

C2607657

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(3 entries)

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• cawiki TIGIT (proteïna)
• enwiki TIGIT
• frwiki TIGIT

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21114021&oldid=2022956490"