ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Q21112346)

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mammalian protein found in Homo sapiens

cockayne syndrome WD repeat protein CSA
excision repair cross-complementation group 8
DNA excision repair protein ERCC-8
Cockayne syndrome WD-repeat protein CSA
excision repair cross-complementing rodent repair deficiency, complementation group 8
ERCC8

Language	Label	Description	Also known as
English	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	mammalian protein found in Homo sapiens	cockayne syndrome WD repeat protein CSA excision repair cross-complementation group 8 DNA excision repair protein ERCC-8 Cockayne syndrome WD-repeat protein CSA excision repair cross-complementing rodent repair deficiency, complementation group 8 ERCC8

Statements

1 reference

13 November 2019

UniProt protein ID

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13216

WD40-repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13216

WD40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

G-protein beta WD-40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ATP-dependent activity, acting on DNA

determination method

1 reference

9 May 2019

Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

DNA helicase activity

determination method

1 reference

9 May 2019

Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

ubiquitin-protein transferase activity

determination method

1 reference

21 June 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

protein binding

determination method

5 references

9 May 2019

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

protein-containing complex binding

determination method

1 reference

9 May 2019

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

ubiquitin-protein transferase activity

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

nucleotide-excision repair complex

determination method

1 reference

21 June 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

determination method

1 reference

9 May 2019

Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

Cul4A-RING E3 ubiquitin ligase complex

determination method

1 reference

21 June 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

1 reference

9 May 2019

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

protein-containing complex

determination method

1 reference

9 May 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

Cul4A-RING E3 ubiquitin ligase complex

determination method

biological process

response to X-ray

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

protein polyubiquitination

determination method

1 reference

21 June 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

positive regulation of DNA repair

determination method

1 reference

21 June 2018

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

21 June 2018

CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

protein ubiquitination

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

protein autoubiquitination

determination method

1 reference

9 May 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

transcription-coupled nucleotide-excision repair

determination method

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

21 June 2018

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

21 June 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

response to oxidative stress

determination method

determination method

3 references

21 June 2018

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

21 June 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13216&geneProductId=UniProtKB:Q13216

determination method

nucleotide-excision repair

determination method

1 reference

9 May 2019

The role of CSA in the response to oxidative DNA damage in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

post-translational protein modification

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

response to auditory stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

response to organic cyclic compound

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

DNA duplex unwinding

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

protein polyubiquitination

determination method

transcription-coupled nucleotide-excision repair

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

8 April 2019

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

8 April 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

transcription-coupled nucleotide-excision repair

determination method

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13216

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13216

G-protein beta WD-40 repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13216

WD40 repeat, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13216

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000265038

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000265038

ENSP00000370510

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370510

ENSP00000408344

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408344

ENSP00000494726

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494726

ENSP00000494199

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494199

ENSP00000494466

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494466

ENSP00000496080

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496080

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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