C-C motif chemokine receptor 1 (Q21111916)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

HM145
C-C chemokine receptor type 1
macrophage inflammatory protein 1-alpha receptor
C-C CKR-1
CCR-1
chemokine (C-C motif) receptor 1
RANTES-R
CCR1
MIP-1alpha-R
CC-CKR-1
LD78 receptor
RANTES receptor
Receptors, CCR1

Language	Label	Description	Also known as
English	C-C motif chemokine receptor 1	mammalian protein found in Homo sapiens	HM145 C-C chemokine receptor type 1 macrophage inflammatory protein 1-alpha receptor C-C CKR-1 CCR-1 chemokine (C-C motif) receptor 1 RANTES-R CCR1 MIP-1alpha-R CC-CKR-1 LD78 receptor RANTES receptor Receptors, CCR1

Statements

1 reference

13 November 2019

UniProt protein ID

C-C Chemokine receptor type 1, eukaryote

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32246

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

C-C chemokine binding

determination method

4 references

16 July 2018

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

16 July 2018

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

16 July 2018

A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

16 July 2018

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

chemokine (C-C motif) ligand 5 binding

determination method

4 references

16 July 2018

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

16 July 2018

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

16 July 2018

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

16 July 2018

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

signal transducer activity

determination method

1 reference

31 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

chemokine (C-C motif) ligand 7 binding

determination method

2 references

16 July 2018

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

16 July 2018

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

protein binding

determination method

7 references

8 April 2019

Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

chemokine receptor activity

determination method

3 references

8 April 2019

Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

phosphatidylinositol phospholipase C activity

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

C-C chemokine receptor activity

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

chemokine binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

C-C chemokine binding

determination method

5 references

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

chemokine (C-C motif) ligand 7 binding

determination method

3 references

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

chemokine (C-C motif) ligand 5 binding

determination method

5 references

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

plasma membrane

determination method

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

external side of plasma membrane

determination method

1 reference

16 July 2018

Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

external side of plasma membrane

determination method

biological process

negative regulation of bone mineralization

determination method

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

positive regulation of cell migration

determination method

1 reference

8 April 2019

The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

16 July 2018

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

determination method

chemokine-mediated signaling pathway

determination method

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

determination method

1 reference

8 April 2019

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

cellular calcium ion homeostasis

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

positive regulation of osteoclast differentiation

determination method

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

dendritic cell chemotaxis

determination method

1 reference

8 April 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

cell surface receptor signaling pathway

determination method

1 reference

8 April 2019

Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

determination method

1 reference

8 April 2019

LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

response to wounding

determination method

1 reference

8 April 2019

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

calcium ion transport

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

positive regulation of calcium ion transport

determination method

1 reference

8 April 2019

A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

determination method

3 references

8 April 2019

PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

inflammatory response

determination method

3 references

8 April 2019

Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

immune response

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

calcium-mediated signaling

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

cell chemotaxis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

determination method

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32246

Identifiers

MeSH descriptor ID

subject named as

Receptors, CCR1

0 references

D12.776.543.750.695.160.150.100

0 references

D12.776.543.750.705.852.125.150.100

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000296140

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000296140

0 references

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P32246.txt?version=142

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(6 entries)

dewiki CCR1
enwiki CCR1
ruwiki CCR1
ttwiki CCR1
ukwiki CCR1
viwiki CCR1

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21111916&oldid=2022947514"