Trinucleotide repeat containing adaptor 6C (Q21111275)

RNA-binding domain superfamily

1 reference

Trinucleotide repeat-containing gene 6C protein

1 reference

Nucleotide-binding alpha-beta plait domain superfamily

1 reference

Ubiquitin-associated domain, protein family

1 reference

TNRC6, PABC binding domain, protein family

1 reference

GW182, middle domain, protein family

1 reference

Argonaute hook domain, protein family

1 reference

TNRC6C, RNA recognition motif, protein family

1 reference

RNA recognition motif domain, protein family

1 reference

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

1 reference

13 November 2019

1 reference

13 November 2019

11 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

8 April 2019

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

1 reference

21 June 2018

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCJ0&geneProductId=UniProtKB:Q9HCJ0

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

IDA

gene silencing by miRNA

1 reference

21 June 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HCJ0&geneProductId=UniProtKB:Q9HCJ0

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

IGI

1 reference

8 April 2019

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

regulation of translation

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

Wnt signaling pathway, calcium modulating pathway

IEA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

regulation of megakaryocyte differentiation

IEA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

negative regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HCJ0

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

Argonaute hook domain

1 reference

TNRC6, PABC binding domain

1 reference

RNA recognition motif domain

1 reference

GW182, middle domain

1 reference

Ubiquitin-associated domain

1 reference

TNRC6C, RNA recognition motif

1 reference