Cholinergic receptor nicotinic alpha 1 subunit (Q21111162)

hierarchical database ID heuristic

Transporter Classification Database ID

1.A.9.1.1

Neurotransmitter-gated ion-channel ligand-binding domain superfamily

1 October 2019

part of

1 reference

Neurotransmitter-gated ion-channel transmembrane domain superfamily

1 reference

Nicotinic acetylcholine receptor

1 reference

cysteine loop ligand-gated ion channel receptor

1 reference

Transporter Classification Database ID

1.A.9.1.1

2 October 2019

hierarchical database ID heuristic

Neurotransmitter-gated ion-channel transmembrane domain, protein family

1 reference

inferred from protein domain or family

Neurotransmitter-gated ion-channel ligand-binding domain, protein family

1 reference

inferred from protein domain or family

Neurotransmitter-gated ion-channel, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

extracellular ligand-gated ion channel activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

acetylcholine receptor activity

3 references

16 July 2018

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

16 July 2018

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

ligand-gated ion channel activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

TAS

acetylcholine binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

acetylcholine-gated cation-selective channel activity

5 references

8 April 2019

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

transmembrane signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

acetylcholine receptor activity

4 references

8 April 2019

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

3 references

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

IDA

neuromuscular junction

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

16 July 2018

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

IDA

postsynaptic membrane

acetylcholine-gated channel complex

NAS

3 references

4 references

8 April 2019

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

integral component of postsynaptic specialization membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

integral component of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

neuromuscular junction

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

muscle cell cellular homeostasis

biological process

1 reference

8 April 2019

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

neuron cellular homeostasis

1 reference

8 April 2019

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

regulation of membrane potential

3 references

16 July 2018

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

16 July 2018

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

synaptic transmission, cholinergic

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

skeletal muscle tissue growth

1 reference

8 April 2019

Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

neuromuscular synaptic transmission

1 reference

16 July 2018

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

Quinidine sulfate therapy for the slow-channel congenital myasthenic syndrome

neuromuscular process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

neuromuscular junction development

1 reference

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders

musculoskeletal movement

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

1 reference

16 July 2018

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

neuronal action potential

TAS

1 reference

8 April 2019

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

regulation of postsynaptic membrane potential

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

excitatory postsynaptic potential

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

ion transmembrane transport

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02708&geneProductId=UniProtKB:P02708

chemical synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

neuromuscular synaptic transmission

regulation of membrane potential

4 references

8 April 2019

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

nervous system process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02708

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4004

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

4001

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

3990

English

17 August 2016

succinylcholine chloride

object has role

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL983

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200527

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201244

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1739

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201206

cisatracurium besylate

object has role

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200641

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL360055

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1360

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200757

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200648

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200629

has part(s)

Neurotransmitter-gated ion-channel transmembrane domain

1 reference

Neurotransmitter-gated ion-channel ligand-binding domain

1 reference

Neurotransmitter-gated ion-channel, conserved site

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

Transporter Classification Database ID

English

1.A.9.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database