Sprouty RTK signaling antagonist 2 (Q21111117)

http://www.ebi.ac.uk/interpro/protein/O43597

1 reference

13 November 2019

1 reference

13 November 2019

protein serine/threonine kinase inhibitor activity

1 reference

8 April 2019

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

protein serine/threonine kinase activator activity

IC

1 reference

8 April 2019

A novel role of Sprouty 2 in regulating cellular apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

10 references

8 April 2019

Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions

IPI

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

microtubule cytoskeleton

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of neurotrophin TRK receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

positive regulation of protein kinase B signaling

1 reference

8 April 2019

A novel role of Sprouty 2 in regulating cellular apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of epidermal growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

bud elongation involved in lung branching

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of peptidyl-threonine phosphorylation

1 reference

8 April 2019

Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

sensory perception of sound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

positive regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

A novel role of Sprouty 2 in regulating cellular apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of fibroblast growth factor receptor signaling pathway

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43597&geneProductId=UniProtKB:O43597

positive regulation of gene expression

1 reference

8 April 2019

A novel role of Sprouty 2 in regulating cellular apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of GTPase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

regulation of signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of MAP kinase activity

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43597&geneProductId=UniProtKB:O43597

inner ear morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

respiratory system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

establishment of mitotic spindle orientation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

A novel role of Sprouty 2 in regulating cellular apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

regulation of cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

branching morphogenesis of an epithelial tube

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

positive regulation of protein serine/threonine kinase activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

positive regulation of cell migration

1 reference

8 April 2019

Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of ERK1 and ERK2 cascade

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43597&geneProductId=UniProtKB:O43597

27 February 2018

Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43597&geneProductId=UniProtKB:O43597

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43597&geneProductId=UniProtKB:O43597

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43597&geneProductId=UniProtKB:O43597

cellular response to leukemia inhibitory factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of angiogenesis

1 reference

8 April 2019

MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

cellular response to vascular endothelial growth factor stimulus

1 reference

8 April 2019

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of ERK1 and ERK2 cascade

IDA

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

8 April 2019

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of vascular endothelial growth factor signaling pathway

IDA

1 reference

8 April 2019

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43597

negative regulation of Ras protein signal transduction

IDA

IBA