Dopamine receptor D1 (Q21110867)

http://www.ebi.ac.uk/interpro/protein/P21728

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

dopamine neurotransmitter receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

dopamine binding

1 reference

16 July 2018

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

dopamine neurotransmitter receptor activity, coupled via Gs

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Molecular cloning and expression of the gene for a human D1 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Cloning and expression of human and rat D1 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

G protein-coupled receptor activity

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

1 reference

1 January 2018

dopamine neurotransmitter receptor activity, coupled via Gs

Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Molecular cloning and expression of the gene for a human D1 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Cloning and expression of human and rat D1 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

G-protein alpha-subunit binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

dopamine binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

1 reference

8 April 2019

ciliary membrane

1 reference

8 April 2019

DISC1 regulates primary cilia that display specific dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

endomembrane system

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

non-motile cilium

1 reference

8 April 2019

DISC1 regulates primary cilia that display specific dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

GABA-ergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

integral component of postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

integral component of presynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

dendritic spine

dendrite

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

1 reference

8 April 2019

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

1 reference

8 April 2019

cilium

1 reference

8 April 2019

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

biological process

1 reference

8 April 2019

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

protein import into nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

positive regulation of potassium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

response to amphetamine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

feeding behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

long-term depression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

temperature homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

striatum development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

prepulse inhibition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

grooming behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

behavioral response to cocaine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

locomotory behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

dentate gyrus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

memory

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

synapse assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

habituation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

peristalsis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

cellular response to catecholamine stimulus

1 reference

8 April 2019

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

adenylate cyclase-activating dopamine receptor signaling pathway

7 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Isoform-specific enhancement of adenylyl cyclase activity by n-alkanols

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Molecular cloning and expression of the gene for a human D1 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Cloning and expression of human and rat D1 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

16 July 2018

Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21728&geneProductId=UniProtKB:P21728

regulation of dopamine uptake involved in synaptic transmission

1 reference

8 April 2019

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

associative learning

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

astrocyte development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

positive regulation of release of sequestered calcium ion into cytosol

behavioral fear response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

dopamine receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

conditioned taste aversion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

glucose import

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

sensitization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

operant conditioning

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

vasodilation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

1 reference

8 April 2019

regulation of dopamine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

dopamine metabolic process

1 reference

8 April 2019

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

phospholipase C-activating dopamine receptor signaling pathway

D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

Maternal behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

dopamine transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

hippocampus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

neuronal action potential

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

long-term potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

1 reference

8 April 2019

synaptic transmission, dopaminergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

positive regulation of gene expression

1 reference

8 April 2019

Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

cellular response to dopamine

1 reference

8 April 2019

Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

adenylate cyclase-activating G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

3 references

8 April 2019

8 April 2019

Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Molecular cloning and expression of the gene for a human D1 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

regulation of synaptic vesicle exocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

adenylate cyclase-activating dopamine receptor signaling pathway

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Isoform-specific enhancement of adenylyl cyclase activity by n-alkanols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Molecular cloning and expression of the gene for a human D1 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Cloning and expression of human and rat D1 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

learning

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21728

physically interacts with

1 reference

6077

17 August 2016

1 reference

33

17 August 2016

1 reference

37

17 August 2016

1 reference

940

17 August 2016

1 reference

939

17 August 2016

1 reference

48

17 August 2016

1 reference

941

17 August 2016

1 reference

5

17 August 2016

1 reference

35

17 August 2016

1 reference

43

17 August 2016

1 reference

935

17 August 2016

1 reference

62

17 August 2016

1 reference

83

17 August 2016

1 reference

38

17 August 2016

1 reference

3304

17 August 2016

1 reference

948

17 August 2016

1 reference

204

17 August 2016

1 reference

86

17 August 2016

1 reference

88

17 August 2016

1 reference

7227

17 August 2016

1 reference

7279

17 August 2016

2 references

943

English

17 August 2016

946

17 August 2016

1 reference

99

17 August 2016

1 reference

100

English

17 August 2016

tavapadon

Partial agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3697617

pimozide

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1423

fenoldopam

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL588

pergolide mesylate

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1275

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21728

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

Guide to Pharmacology Target ID

214

1 reference

Guide to Pharmacology Target ID

214