CD300a molecule (Q21109850)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

CMRF-35-H9
CMRF35-like molecule 8
CD300a antigen
CMRF35H leukocyte immunoglobulin-like receptor
leukocyte membrane antigen
inhibitory receptor protein 60
IgSF12
CMRF35-H
immunoglobulin superfamily member 12
CMRF35-H9
IRp60
IRC1/IRC2
CD300 antigen-like family member A
CD300A
NK inhibitory receptor

Language	Label	Description	Also known as
English	CD300a molecule	mammalian protein found in Homo sapiens	CMRF-35-H9 CMRF35-like molecule 8 CD300a antigen CMRF35H leukocyte immunoglobulin-like receptor leukocyte membrane antigen inhibitory receptor protein 60 IgSF12 CMRF35-H immunoglobulin superfamily member 12 CMRF35-H9 IRp60 IRC1/IRC2 CD300 antigen-like family member A CD300A NK inhibitory receptor

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UGN4

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UGN4

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CD300A.png
1,920 × 975; 384 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phosphatidylethanolamine binding

determination method

1 reference

8 April 2019

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

phosphatidylserine binding

determination method

1 reference

8 April 2019

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

protein binding

determination method

4 references

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

8 April 2019

Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

extracellular exosome

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

8 April 2019

Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

8 April 2019

CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

plasma membrane

determination method

2 references

tertiary granule membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

ficolin-1-rich granule membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

biological process

regulation of T cell receptor signaling pathway

determination method

1 reference

8 April 2019

Differential expression of CD300a/c on human TH1 and TH17 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of eosinophil migration

determination method

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

positive regulation of phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of neutrophil activation

determination method

1 reference

8 April 2019

The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of eosinophil activation

determination method

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

regulation of immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of fibroblast proliferation

determination method

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of MAP kinase activity

determination method

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of mast cell degranulation

determination method

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of mast cell activation involved in immune response

determination method

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of NK T cell activation

determination method

1 reference

8 April 2019

Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of B cell receptor signaling pathway

determination method

1 reference

8 April 2019

CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of activation of Janus kinase activity

determination method

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of phagocytosis, engulfment

determination method

1 reference

8 April 2019

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of B cell proliferation

determination method

1 reference

8 April 2019

CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

signal transduction

determination method

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UGN4&geneProductId=UniProtKB:Q9UGN4

determination method

negative regulation of MyD88-dependent toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

determination method

immunoglobulin V-set domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UGN4

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UGN4

immunoglobulin subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UGN4

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000308188

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000308188

ENSP00000353259

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353259

ENSP00000354564

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354564

ENSP00000376401

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376401

ENSP00000463189

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463189

ENSP00000497133

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497133

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21109850&oldid=2022938818"