mitogen-activated protein kinase kinase 7 (Q21109744)

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mammalian protein found in Homo sapiens

JNKK 2
SAPKK-4
JNK-activating kinase 2
JNK kinase 2
SAPK kinase 4
MAPK/ERK kinase 7
MAP kinase kinase 7
MEK 7
MAP2K7
stress-activated protein kinase kinase 4
c-Jun N-terminal kinase kinase 2
dual specificity mitogen-activated protein kinase kinase 7
SAPKK4

Language	Label	Description	Also known as
English	mitogen-activated protein kinase kinase 7	mammalian protein found in Homo sapiens	JNKK 2 SAPKK-4 JNK-activating kinase 2 JNK kinase 2 SAPK kinase 4 MAPK/ERK kinase 7 MAP kinase kinase 7 MEK 7 MAP2K7 stress-activated protein kinase kinase 4 c-Jun N-terminal kinase kinase 2 dual specificity mitogen-activated protein kinase kinase 7 SAPKK4

Statements

1 reference

13 November 2019

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14733

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

protein tyrosine kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

protein kinase binding

determination method

1 reference

8 April 2019

SP3 acts as a positive regulator on the core promoter of human ZPK gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

magnesium ion binding

determination method

1 reference

8 April 2019

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

determination method

2 references

determination method

1 reference

8 April 2019

Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

protein phosphatase binding

determination method

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

protein binding

determination method

9 references

8 April 2019

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

MAP kinase kinase activity

determination method

1 reference

24 April 2018

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14733&geneProductId=UniProtKB:O14733

determination method

MAP kinase kinase activity

determination method

JUN kinase kinase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

determination method

2 references

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

biological process

determination method

1 reference

8 April 2019

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

signal transduction

determination method

1 reference

8 April 2019

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

positive regulation of telomerase activity

determination method

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

positive regulation of telomere maintenance via telomerase

determination method

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

positive regulation of telomere capping

determination method

1 reference

8 April 2019

High-throughput RNAi screening reveals novel regulators of telomerase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

response to osmotic stress

determination method

1 reference

8 April 2019

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

response to tumor necrosis factor

determination method

1 reference

8 April 2019

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

response to heat

determination method

1 reference

8 April 2019

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

stress-activated MAPK cascade

determination method

1 reference

8 April 2019

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

regulation of mitotic cell cycle

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14733&geneProductId=UniProtKB:O14733

determination method

regulation of apoptotic process

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14733&geneProductId=UniProtKB:O14733

determination method

signal transduction

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

stress-activated protein kinase signaling cascade

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

activation of protein kinase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

8 April 2019

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

Fc-epsilon receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14733

determination method

physically interacts with

allosteric modulator

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14733

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14733

Identifiers

MeSH descriptor ID

subject named as

MAP Kinase Kinase 7

0 references

D08.811.913.696.620.682.700.565.700

0 references

D08.811.913.696.620.682.725.200.700

0 references

D12.776.476.563.565.700

0 references

D12.776.476.568.200.700

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000381066

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381066

ENSP00000381068

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381068

ENSP00000381070

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381070

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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