Arachidonate 12-lipoxygenase, 12R type (Q21107911)

http://www.ebi.ac.uk/interpro/protein/O75342

PLAT/LH2 domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75342

Lipoxygenase, mammalian

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75342

Lipoxygenase, C-terminal domain, protein family

1 reference

Lipoxygenase, iron binding site, protein family

1 reference

PLAT/LH2 domain, protein family

1 reference

Lipoxygenase, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

1 reference

18 July 2018

1 reference

18 July 2018

1 reference

8 April 2019

arachidonate 12(S)-lipoxygenase activity

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75342&geneProductId=UniProtKB:O75342

27 March 2018

Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75342&geneProductId=UniProtKB:O75342

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75342&geneProductId=UniProtKB:O75342

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

1 reference

8 April 2019

The expression of epidermal lipoxygenases and transglutaminase-1 is perturbed by NIPAL4 mutations: indications of a common metabolic pathway essential for skin barrier homeostasis

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

oxidoreductase activity

1 reference

8 April 2019

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

IDA

linoleate 9S-lipoxygenase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

arachidonate 12(S)-lipoxygenase activity

1 reference

1 January 2018

Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

fatty acid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

8 April 2019

Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

8 April 2019

Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

hepoxilin biosynthetic process

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

positive regulation of gene expression

1 reference

8 April 2019

A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

positive regulation of mucus secretion

IMP

1 reference

8 April 2019

A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

positive regulation of MAPK cascade

IMP

1 reference

8 April 2019

A role for 12R-lipoxygenase in MUC5AC expression by respiratory epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

arachidonic acid metabolic process

IDA

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

8 April 2019

Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

linoleic acid metabolic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

ceramide biosynthetic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342

establishment of skin barrier

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75342