TLE family member 1, transcriptional corepressor (Q21107568)

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mammalian protein found in Homo sapiens

TLE1
E(Sp1) homolog
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
transducin like enhancer of split 1
ESG1
transducin-like enhancer protein 1
enhancer of split groucho-like protein 1
TLE1 protein, human
Transducin-like enhancer protein 1

Language	Label	Description	Also known as
English	TLE family member 1, transcriptional corepressor	mammalian protein found in Homo sapiens	TLE1 E(Sp1) homolog transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) transducin like enhancer of split 1 ESG1 transducin-like enhancer protein 1 enhancer of split groucho-like protein 1 TLE1 protein, human Transducin-like enhancer protein 1

Statements

1 reference

13 November 2019

UniProt protein ID

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04724

WD40-repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04724

Groucho/transducin-like enhancer

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q04724

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5T3G3

Groucho/TLE, N-terminal Q-rich domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

UniProt protein ID

UniProt protein ID

17 September 2016

2 references

13 November 2019

UniProt protein ID

UniProt protein ID

30 June 2016

language of work or name

molecular function

transcription corepressor activity

determination method

2 references

transcription factor binding

determination method

protein binding

determination method

8 references

8 April 2019

Six3 and Six6 activity is modulated by members of the groucho family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Molecular functions of the TLE tetramerization domain in Wnt target gene repression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

identical protein binding

determination method

1 reference

8 April 2019

Molecular functions of the TLE tetramerization domain in Wnt target gene repression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

determination method

1 reference

8 April 2019

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

determination method

5 references

5 June 2018

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

determination method

5 June 2018

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

determination method

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

determination method

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

determination method

5 June 2018

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

beta-catenin-TCF complex

determination method

1 reference

8 April 2019

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

determination method

6 references

8 April 2019

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

transcription regulator complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

determination method

1 reference

UniProt protein ID

30 June 2016

language of work or name

determination method

1 reference

UniProt protein ID

30 June 2016

language of work or name

determination method

1 reference

UniProt protein ID

30 June 2016

language of work or name

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T3G3

determination method

biological process

negative regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

Wnt signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

negative regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

transcription, DNA-templated

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

determination method

multicellular organism development

determination method

1 reference

8 April 2019

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

animal organ morphogenesis

determination method

1 reference

8 April 2019

Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

signal transduction

determination method

1 reference

8 April 2019

Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

determination method

beta-catenin-TCF complex assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

negative regulation of canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Identifiers

MeSH descriptor ID

subject named as

TLE1 protein, human

0 references

RefSeq protein ID

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

Ensembl protein ID

ENSP00000365682

1 reference

ensembl Release 98

Ensembl protein ID

ENSP00000365682

ENSP00000365646

1 reference

ensembl Release 98

Ensembl protein ID

ENSP00000365646

ENSP00000365667

1 reference

ensembl Release 98

Ensembl protein ID

ENSP00000365667

ENSP00000391347

1 reference

ensembl Release 98

Ensembl protein ID

ENSP00000391347

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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