GA binding protein transcription factor subunit alpha (Q21107537)

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mammalian protein found in Homo sapiens

nuclear respiratory factor 2 subunit alpha
nuclear respiratory factor 2 alpha subunit
GABPA
GA binding protein transcription factor alpha subunit 60kDa
GA-binding protein alpha chain
human nuclear respiratory factor-2 subunit alpha
transcription factor E4TF1-60
GABP subunit alpha

Language	Label	Description	Also known as
English	GA binding protein transcription factor subunit alpha	mammalian protein found in Homo sapiens	nuclear respiratory factor 2 subunit alpha nuclear respiratory factor 2 alpha subunit GABPA GA binding protein transcription factor alpha subunit 60kDa GA-binding protein alpha chain human nuclear respiratory factor-2 subunit alpha transcription factor E4TF1-60 GABP subunit alpha

Statements

1 reference

13 November 2019

UniProt protein ID

winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q06546

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q06546

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q06546

Transcription factor, GA-binding, alpha subunit

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q06546

Sterile alpha motif/pointed domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q06546

GA-binding protein alpha subunit, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ETS transcription factor family

1 reference

based on heuristic

inferred from protein domain or family

Pointed domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

sequence-specific DNA binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

DNA-binding transcription factor activity

determination method

3 references

8 April 2019

cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Mapping of the human transcription factor GABPA (E4TF1-60) gene to chromosome 21

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

10 September 2018

Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

chromatin binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

2 references

8 April 2019

Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

protein binding

determination method

1 reference

8 April 2019

The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

27 March 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

27 March 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

27 March 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

determination method

5 references

27 March 2018

Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

27 March 2018

Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

determination method

6 references

8 April 2019

Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

biological process

cell differentiation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

mitochondrion organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

in utero embryonic development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

negative regulation of megakaryocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06546&geneProductId=UniProtKB:Q06546

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

8 April 2019

METTL23, a transcriptional partner of GABPA, is essential for human cognition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

8 April 2019

Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

transcription by RNA polymerase II

determination method

1 reference

8 April 2019

cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

cellular response to dopamine

determination method

1 reference

8 April 2019

Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

blastocyst formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06546

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q06546

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q06546

GA-binding protein alpha subunit, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q06546

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000346886

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000346886

ENSP00000382948

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000382948

PDB structure ID

1 reference

9 November 2015

http://www.uniprot.org/uniprot/Q00422.txt?version=148

1 reference

9 November 2015

http://www.uniprot.org/uniprot/Q00422.txt?version=148

1 reference

9 November 2015

http://www.uniprot.org/uniprot/Q00422.txt?version=148

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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