Serine hydroxymethyltransferase 2 (Q21106465)

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mammalian protein found in Homo sapiens
  • threonine aldolase
  • glycine auxotroph A, human complement for hamster
  • epididymis secretory sperm binding protein Li 51e
  • serine hydroxymethyltransferase, mitochondrial
  • GLY A+
  • glycine hydroxymethyltransferase
  • serine methylase
  • SHMT2
  • serine hydroxymethylase
  • serine hydroxymethyltransferase 2 (mitochondrial)
  • serine aldolase
edit
Language Label Description Also known as
English
Serine hydroxymethyltransferase 2
mammalian protein found in Homo sapiens
  • threonine aldolase
  • glycine auxotroph A, human complement for hamster
  • epididymis secretory sperm binding protein Li 51e
  • serine hydroxymethyltransferase, mitochondrial
  • GLY A+
  • glycine hydroxymethyltransferase
  • serine methylase
  • SHMT2
  • serine hydroxymethylase
  • serine hydroxymethyltransferase 2 (mitochondrial)
  • serine aldolase

Statements

molecular function
glycine hydroxymethyltransferase activity
determination method
IEA
IDA
TAS
8 references
retrieved
26 September 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
TAS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
26 September 2017
stated in
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
26 September 2017
stated in
Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
26 September 2017
stated in
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
26 September 2017
stated in
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
glycine hydroxymethyltransferase activity
determination method
IBA
IDA
IEA
TAS
12 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
1 January 2018
stated in
Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
1 January 2018
stated in
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
1 January 2018
stated in
Mitochondrial translation requires folate-dependent tRNA methylation
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
1 January 2018
stated in
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
1 January 2018
stated in
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
1 January 2018
stated in
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
1 January 2018
stated in
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IBA
glycine hydroxymethyltransferase activity
determination method
IBA
IDA
IEA
11 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
8 April 2019
stated in
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
Mitochondrial translation requires folate-dependent tRNA methylation
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IBA
cell component
mitochondrion
determination method
IEA
IDA
6 references
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
26 September 2017
stated in
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
26 September 2017
stated in
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
26 September 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
26 September 2017
stated in
SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P34897&geneProductId=UniProtKB:P34897
determination method
IDA
biological process
one-carbon metabolic process
determination method
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IEA
retrieved
8 April 2019
stated in
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
Mitochondrial translation requires folate-dependent tRNA methylation
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
GOA
curator
UniProt
UniProt protein ID
P34897
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34897
determination method
IBA

Identifiers

Ensembl protein ID
 
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