WASH complex subunit 2C (Q21106096)

mammalian protein found in Homo sapiens

WASHC2C
VPEF
vaccinia virus penetration factor
WASH complex subunit FAM21C
family with sequence similarity 21 member C

Language	Label	Description	Also known as
English	WASH complex subunit 2C	mammalian protein found in Homo sapiens	WASHC2C VPEF vaccinia virus penetration factor WASH complex subunit FAM21C family with sequence similarity 21 member C

Statements

1 reference

13 November 2019

transporter of unknown biochemical mechanism

1 reference

Transporter Classification Database ID

9.A.3.1.2

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

FAM21/CAPZIP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

phosphatidylinositol-3-phosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-3,5-bisphosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-3,4-bisphosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-4-phosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-5-phosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

5 references

8 April 2019

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

8 April 2019

A FAM21-containing WASH complex regulates retromer-dependent sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

8 April 2019

Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

8 April 2019

Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

8 April 2019

RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IPI

phosphatidylinositol-4,5-bisphosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-3,4,5-trisphosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IEA

retromer complex binding

1 reference

16 July 2018

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4E1&geneProductId=UniProtKB:Q9Y4E1

determination method

IMP

retromer complex binding

early endosome membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IEA

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

16 July 2018

Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4E1&geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

A FAM21-containing WASH complex regulates retromer-dependent sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

biological process

negative regulation of barbed-end actin filament capping

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

retrograde transport, endosome to Golgi

1 reference

8 April 2019

A FAM21-containing WASH complex regulates retromer-dependent sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IEA

regulation of substrate adhesion-dependent cell spreading

1 reference

8 April 2019

Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

protein localization to endosome

1 reference

8 April 2019

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9Y4E1

Identifiers

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30 May 2020

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13 November 2019

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Transporter Classification Database ID

9.A.3.1.2

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

WASH complex subunit 2C (Q21106096)

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Identifiers

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WASH complex subunit 2C (Q21106096)

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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