Tropomyosin 1 (Q21105496)

http://www.ebi.ac.uk/interpro/protein/P09493

1 reference

13 November 2019

1 reference

13 November 2019

cytoskeletal protein binding

1 reference

8 April 2019

Nebulette interacts with filamin C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

structural constituent of cytoskeleton

IPI

1 reference

8 April 2019

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

4 references

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

structural constituent of muscle

IPI

1 reference

8 April 2019

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

identical protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

muscle thin filament tropomyosin

actin filament binding

3 references

1 reference

8 April 2019

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09493&geneProductId=UniProtKB:P09493

regulation of muscle contraction

IEA

biological process

1 reference

8 April 2019

Human hTM alpha gene: expression in muscle and nonmuscle tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

regulation of heart contraction

1 reference

8 April 2019

Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

positive regulation of ATP-dependent activity

1 reference

8 April 2019

Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

negative regulation of vascular associated smooth muscle cell migration

1 reference

8 April 2019

MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

negative regulation of vascular associated smooth muscle cell proliferation

IMP

1 reference

8 April 2019

MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

1 reference

8 April 2019

Role of high-molecular weight tropomyosins in TGF-beta-mediated control of cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

cellular response to reactive oxygen species

1 reference

8 April 2019

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

negative regulation of cell migration

IEP

1 reference

8 April 2019

Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

cytoskeleton organization

1 reference

8 April 2019

Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities

regulation of cell shape

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy

IMP

sarcomere organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

positive regulation of stress fiber assembly

IMP

1 reference

8 April 2019

Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

positive regulation of cell adhesion

1 reference

8 April 2019

Role of high-molecular weight tropomyosins in TGF-beta-mediated control of cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

actin filament organization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

in utero embryonic development

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

cardiac muscle contraction

IEA

2 references

21 June 2018

Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09493&geneProductId=UniProtKB:P09493

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09493&geneProductId=UniProtKB:P09493

cardiac muscle contraction

IEA

3 references

8 April 2019

Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09493