APC regulator of WNT signaling pathway 2 (Q21105220)

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mammalian protein found in Homo sapiens

Adenomatous polyposis coli protein-like
APC2, WNT signaling pathway regulator
APC-like
APC2
adenomatous polyposis coli protein 2
adenomatous polyposis coli like
adenomatosis polyposis coli 2

Language	Label	Description	Also known as
English	APC regulator of WNT signaling pathway 2	mammalian protein found in Homo sapiens	Adenomatous polyposis coli protein-like APC2, WNT signaling pathway regulator APC-like APC2 adenomatous polyposis coli protein 2 adenomatous polyposis coli like adenomatosis polyposis coli 2

Statements

1 reference

13 November 2019

UniProt protein ID

Adenomatous polyposis coli 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

Armadillo-like helical

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

adenomatous polyposis coli protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

APC, N-terminal coiled-coil domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

Adenomatous polyposis coli, N-terminal dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Adenomatous polyposis coli protein basic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

armadillo domain proteins

1 reference

based on heuristic

inferred from protein domain or family

SAMP, protein family

1 reference

based on heuristic

inferred from protein domain or family

Armadillo domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Adenomatous polyposis coli protein repeat family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

microtubule binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

protein binding

determination method

4 references

8 April 2019

EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

beta-catenin binding

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

gamma-catenin binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

microtubule cytoskeleton

determination method

1 reference

8 April 2019

EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

determination method

1 reference

8 April 2019

Human APC2 localization and allelic imbalance

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

perinuclear region of cytoplasm

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

Human APC2 localization and allelic imbalance

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

cytoplasmic microtubule

determination method

3 references

27 March 2018

Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95996&geneProductId=UniProtKB:O95996

determination method

27 March 2018

Human APC2 localization and allelic imbalance

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95996&geneProductId=UniProtKB:O95996

determination method

27 March 2018

EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95996&geneProductId=UniProtKB:O95996

determination method

catenin complex

determination method

1 reference

8 April 2019

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

lamellipodium membrane

determination method

1 reference

8 April 2019

Human APC2 localization and allelic imbalance

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

filamentous actin

determination method

1 reference

8 April 2019

Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

intercellular bridge

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

cytoplasmic microtubule

determination method

4 references

8 April 2019

Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

Human APC2 localization and allelic imbalance

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

beta-catenin destruction complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

biological process

negative regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

negative regulation of canonical Wnt signaling pathway

determination method

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95996&geneProductId=UniProtKB:O95996

determination method

27 March 2018

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95996&geneProductId=UniProtKB:O95996

determination method

27 March 2018

Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95996&geneProductId=UniProtKB:O95996

determination method

microtubule cytoskeleton organization

determination method

1 reference

8 April 2019

Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

activation of GTPase activity

determination method

1 reference

8 April 2019

Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

cell fate specification

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

negative regulation of microtubule depolymerization

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

pattern specification process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

regulation of cell differentiation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

positive regulation of protein catabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

negative regulation of canonical Wnt signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95996

determination method

Adenomatous polyposis coli, N-terminal dimerisation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

Adenomatous polyposis coli protein repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

Adenomatous polyposis coli protein basic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95996

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000233607

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000233607

ENSP00000442954

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442954

ENSP00000238483

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000238483

ENSP00000466173

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466173

ENSP00000466803

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466803

ENSP00000467073

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467073

ENSP00000468199

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468199

PDB structure ID

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

1 reference

15 October 2015

http://www.uniprot.org/uniprot/P25054.txt?203

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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