Tripartite motif containing 21 (Q21103284)

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mammalian protein found in Homo sapiens

52 kDa Ro protein
RING-type E3 ubiquitin transferase TRIM21
TRIM21
Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
sjoegren syndrome type A antigen
RING finger protein 81
52 kDa ribonucleoprotein autoantigen Ro/SS-A
E3 ubiquitin-protein ligase TRIM21
SS-A
tripartite motif-containing protein 21
Sicca syndrome antigen A
ro(SS-A)
Ro/SSA 52kDa

Language	Label	Description	Also known as
English	Tripartite motif containing 21	mammalian protein found in Homo sapiens	52 kDa Ro protein RING-type E3 ubiquitin transferase TRIM21 TRIM21 Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro) sjoegren syndrome type A antigen RING finger protein 81 52 kDa ribonucleoprotein autoantigen Ro/SS-A E3 ubiquitin-protein ligase TRIM21 SS-A tripartite motif-containing protein 21 Sicca syndrome antigen A ro(SS-A) Ro/SSA 52kDa

Statements

1 reference

13 November 2019

UniProt protein ID

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

Butyrophylin-like, SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B30.2/SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, B-box, chordata, protein family

1 reference

based on heuristic

inferred from protein domain or family

B-box-type zinc finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

U box domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TRIM21, PRY/SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

protein binding

determination method

7 references

8 April 2019

Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

identical protein binding

determination method

3 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

ubiquitin-protein transferase activity

determination method

8 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

7 November 2018

Autoantigen Ro52 is an E3 ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

7 November 2018

UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

7 November 2018

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

7 November 2018

Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

7 November 2018

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

7 November 2018

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

ubiquitin-protein transferase activity

determination method

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Autoantigen Ro52 is an E3 ubiquitin ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

SCF ubiquitin ligase complex

determination method

1 reference

8 April 2019

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

intracellular anatomical structure

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

ribonucleoprotein complex

determination method

1 reference

8 April 2019

Expression and DNA binding of the human 52 kDa Ro/SSA autoantigen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

biological process

negative regulation of protein deubiquitination

determination method

1 reference

8 April 2019

UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

response to interferon-gamma

determination method

1 reference

8 April 2019

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

positive regulation of autophagy

determination method

1 reference

8 April 2019

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

interferon-gamma-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

protein trimerization

determination method

1 reference

8 April 2019

Unique features of TRIM5alpha among closely related human TRIM family members

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

positive regulation of viral entry into host cell

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

positive regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

regulation of type I interferon production

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

positive regulation of cell cycle

determination method

1 reference

8 April 2019

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

protein destabilization

determination method

1 reference

8 April 2019

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

protein ubiquitination

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

8 April 2019

UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

protein autoubiquitination

determination method

1 reference

8 April 2019

Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

innate immune response

determination method

1 reference

8 April 2019

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

negative regulation of viral transcription

determination method

1 reference

8 April 2019

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474

determination method

Zinc finger, RING-type, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

SPRY-associated

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

Butyrophylin-like, SPRY domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

B30.2/SPRY domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

Zinc finger, B-box, chordata

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

B-box-type zinc finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

TRIM21, PRY/SPRY domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P19474

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000254436

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000254436

ENSP00000434053

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434053

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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