Carbonyl reductase 4 (Q21102252)

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mammalian protein found in Homo sapiens

short chain dehydrogenase/reductase family 45C member 1
1.1.1.-
carbonyl reductase family member 4
CBR4
quinone reductase CBR4
3-ketoacyl-[acyl-carrier-protein] reductase beta subunit
3-oxoacyl-[acyl-carrier-protein] reductase
KAR beta subunit
carbonic reductase 4

Language	Label	Description	Also known as
English	Carbonyl reductase 4	mammalian protein found in Homo sapiens	short chain dehydrogenase/reductase family 45C member 1 1.1.1.- carbonyl reductase family member 4 CBR4 quinone reductase CBR4 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit 3-oxoacyl-[acyl-carrier-protein] reductase KAR beta subunit carbonic reductase 4

Statements

1 reference

13 November 2019

UniProt protein ID

NAD(P)-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N4T8

Short-chain dehydrogenase/reductase SDR

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N4T8

Short-chain dehydrogenase/reductase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

NAD(P)H dehydrogenase (quinone) activity

determination method

1 reference

9 May 2019

Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

protein binding

determination method

determination method

3 references

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N4T8&geneProductId=UniProtKB:Q8N4T8

determination method

7 November 2018

Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N4T8&geneProductId=UniProtKB:Q8N4T8

determination method

7 November 2018

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N4T8&geneProductId=UniProtKB:Q8N4T8

determination method

3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity

determination method

1 reference

9 May 2019

Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

NADPH dehydrogenase (quinone) activity

determination method

1 reference

9 May 2019

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

quinone binding

determination method

1 reference

8 April 2019

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

determination method

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

mitochondrial matrix

determination method

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N4T8&geneProductId=UniProtKB:Q8N4T8

determination method

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N4T8&geneProductId=UniProtKB:Q8N4T8

determination method

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N4T8&geneProductId=UniProtKB:Q8N4T8

determination method

7 November 2018

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N4T8&geneProductId=UniProtKB:Q8N4T8

determination method

oxidoreductase complex

determination method

1 reference

9 May 2019

Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

mitochondrial matrix

determination method

3 references

biological process

protein homotetramerization

determination method

1 reference

7 November 2018

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N4T8&geneProductId=UniProtKB:Q8N4T8

determination method

daunorubicin metabolic process

determination method

1 reference

9 May 2019

Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

doxorubicin metabolic process

determination method

1 reference

9 May 2019

Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

fatty acid metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

lipid metabolism

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

protein heterotetramerization

determination method

1 reference

9 May 2019

Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

protein homotetramerization

determination method

1 reference

9 May 2019

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

fatty-acyl-CoA biosynthetic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

fatty acid biosynthetic process

determination method

3 references

9 May 2019

Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N4T8

determination method

EC enzyme number

1.1.1.-

1 reference

14 November 2015

http://www.uniprot.org/uniprot/Q8N4T8.txt?version=108

Short-chain dehydrogenase/reductase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N4T8

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000303525

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000303525

ENSP00000427615

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427615

ENSP00000421254

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421254

ENSP00000423128

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423128

ENSP00000424717

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424717

ENSP00000425671

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425671

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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