DNA fragmentation factor subunit alpha (Q21101092)

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mammalian protein found in Homo sapiens

ICAD
DFF45
DNA fragmentation factor 45 kDa subunit
DNA fragmentation factor, 45kDa, alpha polypeptide
DFFA
DFF-45
inhibitor of CAD

Language	Label	Description	Also known as
English	DNA fragmentation factor subunit alpha	mammalian protein found in Homo sapiens	ICAD DFF45 DNA fragmentation factor 45 kDa subunit DNA fragmentation factor, 45kDa, alpha polypeptide DFFA DFF-45 inhibitor of CAD

Statements

1 reference

13 November 2019

UniProt protein ID

DNA fragmentation factor 45kDa, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00273

DNA fragmentation factor 45

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00273

DNA fragmentation factor 45kDa, middle domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CIDE-N domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

3 references

8 April 2019

Identification of ICAD-derived peptides capable of inhibiting caspase-activated DNase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

8 April 2019

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

8 April 2019

Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

protein folding chaperone activity

determination method

1 reference

8 April 2019

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

deoxyribonuclease inhibitor activity

determination method

1 reference

27 March 2018

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00273&geneProductId=UniProtKB:O00273

determination method

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

8 April 2019

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

8 April 2019

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

intracellular anatomical structure

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00273&geneProductId=UniProtKB:O00273

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

plasma membrane

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

biological process

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

negative regulation of execution phase of apoptosis

determination method

1 reference

27 March 2018

CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00273&geneProductId=UniProtKB:O00273

determination method

apoptotic DNA fragmentation

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00273&geneProductId=UniProtKB:O00273

determination method

thymocyte apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

negative regulation of deoxyribonuclease activity

determination method

1 reference

8 April 2019

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

chaperone-mediated protein folding

determination method

1 reference

8 April 2019

Fifty C-terminal amino acid residues are necessary for the chaperone activity of DFF45 but not for the inhibition of DFF40

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00273

determination method

DNA fragmentation factor 45kDa, middle domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00273

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00273

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000366235

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366235

ENSP00000366237

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366237

ENSP00000468395

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468395

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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