RELB proto-oncogene, NF-kB subunit (Q21100854)

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mammalian protein found in Homo sapiens

v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
I-Rel
transcription factor RelB
v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
RELB

Language	Label	Description	Also known as
English	RELB proto-oncogene, NF-kB subunit	mammalian protein found in Homo sapiens	v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 I-Rel transcription factor RelB v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) RELB

Statements

1 reference

13 November 2019

UniProt protein ID

p53-like transcription factor, DNA-binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

Transcription factor RelB

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

Immunoglobulin E-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

Rel homology domain (RHD), DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

IPT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

RelB transactivation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

RelB leucine zipper, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology domain (RHD), DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NFkappaB IPT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rel homology domain, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

transcription corepressor activity

determination method

1 reference

8 April 2019

I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

chromatin binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

protein binding

determination method

7 references

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

COMMD proteins, a novel family of structural and functional homologs of MURR1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Profiling cellular protein complexes by proximity ligation with dual tag microarray readout

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

identical protein binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

7 November 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01201&geneProductId=UniProtKB:Q01201

determination method

7 November 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01201&geneProductId=UniProtKB:Q01201

determination method

7 November 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01201&geneProductId=UniProtKB:Q01201

determination method

I-kappaB/NF-kappaB complex

determination method

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01201&geneProductId=UniProtKB:Q01201

determination method

microtubule organizing center

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

determination method

2 references

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

determination method

1 reference

8 April 2019

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

determination method

transcription repressor complex

determination method

1 reference

8 April 2019

Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

biological process

response to cytokine

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

antigen processing and presentation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

rhythmic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

myeloid dendritic cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

stimulatory C-type lectin receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

T-helper 1 cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

negative regulation of interferon-beta production

determination method

1 reference

8 April 2019

Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

transcription, DNA-templated

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01201&geneProductId=UniProtKB:Q01201

determination method

cellular response to osmotic stress

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

NIK/NF-kappaB signaling

determination method

T-helper 1 type immune response

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

inflammatory response

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

innate immune response

determination method

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01201&geneProductId=UniProtKB:Q01201

determination method

lymphocyte differentiation

determination method

1 reference

8 April 2019

The effects of RelB deficiency on lymphocyte development and function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01201

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

Rel homology dimerisation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

Rel homology domain, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

RelB transactivation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

RelB leucine zipper

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

Rel homology domain (RHD), DNA-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

NFkappaB IPT domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01201

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000221452

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000221452

ENSP00000485826

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485826

ENSP00000423287

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423287

ENSP00000427348

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427348

ENSP00000468460

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468460

PDB structure ID

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q04863.txt?version=129

Sitelinks

Wikipedia(0 entries)

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Wikiquote(0 entries)

Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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