Pim-1 proto-oncogene, serine/threonine kinase (Q21100324)

serine/threonine-protein kinase pim-1/2/3

1 reference

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

protein kinase activity

1 reference

8 April 2019

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

manganese ion binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

ribosomal small subunit binding

1 reference

8 April 2019

Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

transcription factor binding

IPI

1 reference

8 April 2019

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

protein serine/threonine kinase activity

4 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309

31 January 2018

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309

31 January 2018

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309

4 references

8 April 2019

The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

protein serine/threonine kinase activity

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309

31 January 2018

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309

31 January 2018

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

negative regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

multicellular organism development

1 reference

8 April 2019

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

TAS

protein phosphorylation

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

8 April 2019

Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

hyaluronan metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

protein autophosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

cell population proliferation

1 reference

8 April 2019

The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

vitamin D receptor signaling pathway

1 reference

8 April 2019

PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

regulation of mitotic cell cycle

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309

positive regulation of cardiac muscle cell proliferation

IBA

1 reference

8 April 2019

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

positive regulation of cardioblast proliferation

1 reference

8 April 2019

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

cytokine-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

positive regulation of transcription, DNA-templated

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

protein stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

regulation of hematopoietic stem cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5263

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1952329

has part(s)

serine/threonine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

D08.811.913.696.620.682.700.776

Identifiers

MeSH descriptor ID

D051573

subject named as

Proto-Oncogene Proteins c-pim-1

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MeSH tree code

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D12.776.624.664.700.191

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30 May 2020

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30 May 2020

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13 November 2019

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4 August 2016

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4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference