Beclin 1 (Q21097409)

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mammalian protein found in Homo sapiens
  • BECN1
  • ATG6 autophagy related 6 homolog
  • testis secretory sperm-binding protein Li 215e
  • coiled-coil myosin-like BCL2-interacting protein
  • Protein GT197
  • beclin 1, autophagy related
  • beclin-1
  • beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
  • Beclin-1
  • BECN1 protein, human
edit
Language Label Description Also known as
English
Beclin 1
mammalian protein found in Homo sapiens
  • BECN1
  • ATG6 autophagy related 6 homolog
  • testis secretory sperm-binding protein Li 215e
  • coiled-coil myosin-like BCL2-interacting protein
  • Protein GT197
  • beclin 1, autophagy related
  • beclin-1
  • beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
  • Beclin-1
  • BECN1 protein, human

Statements

part of
Beclin-1
0 references
molecular function
protein binding
determination method
IPI
49 references
retrieved
8 April 2019
stated in
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Placental autophagy regulation by the BOK-MCL1 rheostat
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
NRBF2 regulates macroautophagy as a component of Vps34 Complex I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a candidate therapeutic autophagy-inducing peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
A kinase-independent role for EGF receptor in autophagy initiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Endogenous HMGB1 regulates autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Polyglutamine tracts regulate beclin 1-dependent autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Rab39a interacts with phosphatidylinositol 3-kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Targeting  -Herpesvirus 68 Bcl-2-mediated Down-regulation of Autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
The VMP1-Beclin 1 interaction regulates autophagy induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
WASH inhibits autophagy through suppression of Beclin 1 ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
An integrated approach to elucidate the intra-viral and viral-cellular protein interaction networks of a gamma-herpesvirus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Control of autophagic cell death by caspase-10 in multiple myeloma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Beclin-1 is required for chromosome congression and proper outer kinetochore assembly.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
The IKK complex contributes to the induction of autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of autophagy by TAB2 and TAB3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IPI
cell component
biological process
autophagy
determination method
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IMP
retrieved
8 April 2019
stated in
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q14457
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IEA
retrieved
8 April 2019
stated in
Deacetylation of p53 induces autophagy by suppressing Bmf expression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14457
determination method
IDA

Identifiers

MeSH descriptor ID
C491997
subject named as
BECN1 protein, human
0 references
 
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