FES proto-oncogene, tyrosine kinase (Q21097215)

AH/BAR domain superfamily

1 reference

Protein kinase-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

FCH domain, protein family

1 reference

SH2 domain, protein family

1 reference

F-BAR domain, protein family

1 reference

Fes/Fps/Fer, SH2 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

immunoglobulin receptor binding

1 reference

8 April 2019

Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

3 references

8 April 2019

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

phosphatidylinositol binding

IPI

1 reference

8 April 2019

Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

protein tyrosine kinase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

non-membrane spanning protein tyrosine kinase activity

IDA

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

extrinsic component of cytoplasmic side of plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

extrinsic component of cytoplasmic side of plasma membrane

3 references

8 April 2019

Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

regulation of vesicle-mediated transport

1 reference

8 April 2019

Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

regulation of cell motility

TAS

1 reference

8 April 2019

Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

multicellular organism development

1 reference

1 January 2018

Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

regulation of cell adhesion

1 reference

8 April 2019

A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

regulation of cell population proliferation

1 reference

27 March 2018

A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07332&geneProductId=UniProtKB:P07332

microtubule bundle formation

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

regulation of cell shape

positive regulation of neuron projection development

1 reference

8 April 2019

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

positive regulation of microtubule polymerization

1 reference

8 April 2019

The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

peptidyl-tyrosine autophosphorylation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07332&geneProductId=UniProtKB:P07332

regulation of cell differentiation

1 reference

8 April 2019

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

protein autophosphorylation

1 reference

8 April 2019

Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

peptidyl-tyrosine phosphorylation

IDA

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

8 April 2019

A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

regulation of mast cell degranulation

IDA

1 reference

27 March 2018

Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07332&geneProductId=UniProtKB:P07332

cell population proliferation

1 reference

1 January 2018

Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07332&geneProductId=UniProtKB:P07332

TAS

innate immune response

1 reference

27 March 2018

positive regulation of actin cytoskeleton reorganization

1 reference

8 April 2019

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

positive regulation of myeloid cell differentiation

1 reference

8 April 2019

K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

epidermal growth factor receptor signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07332&geneProductId=UniProtKB:P07332

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07332&geneProductId=UniProtKB:P07332

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

regulation of cell population proliferation

regulation of mast cell degranulation

positive regulation of monocyte differentiation

1 reference

8 April 2019

MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

cellular response to vitamin D

1 reference

8 April 2019

MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07332

protein phosphorylation

1 reference

8 April 2019

1 reference

tyrosine-protein kinase, active site

1 reference

FCH domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

SH2 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Fes/Fps/Fer, SH2 domain

1 reference

D08.811.913.696.620.682.725.300

Identifiers

MeSH descriptor ID

D051578

subject named as

Proto-Oncogene Proteins c-fes

0 references

MeSH tree code

0 references

D12.776.476.568.300

0 references

D12.776.624.664.700.177

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

15 June 2016

1 reference

15 June 2016

1 reference

15 June 2016

1 reference

15 June 2016

1 reference

15 June 2016

1 reference

15 June 2016

1 reference

15 June 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference